Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine
| Autor: | Jonathan R. Seckl, Joyce L.W. Yau, June Noble, Karen E. Chapman |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Hippocampus Hippocampal formation Pharmacology Biology Cellular and Molecular Neuroscience Exon chemistry.chemical_compound Receptors Glucocorticoid Glucocorticoid receptor Fluoxetine Desipramine Internal medicine medicine Animals Protein Isoforms Tianeptine RNA Messenger Neurotransmitter Molecular Biology Brain Exons Rats Endocrinology Gene Expression Regulation chemistry Antidepressive Agents Second-Generation medicine.drug |
| Zdroj: | Molecular Brain Research. 129:189-192 |
| ISSN: | 0169-328X |
| DOI: | 10.1016/j.molbrainres.2004.06.033 |
| Popis: | Adult rats were given antidepressant drugs orally. Fluoxetine, but not moclobemide, venlafaxine, tianeptine or desipramine, increased total glucocorticoid receptor (GR) mRNA in the hippocampus after 4 weeks. Further examination revealed that GR mRNA containing the brain-specific exon 1(7) was increased across all hippocampal subregions. In contrast, expression of the major exon 1(10) and another brain-specific exon 1(5)-containing GR mRNAs were unchanged. Tissue-specific first exon usage may contribute to the differential regulation of GR by fluoxetine in brain subregions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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