Comparison of persistent thallium perfusion defects by quantitative washout analysis with thallium reinjection in patients with coronary artery disease
| Autor: | L. Leonardo Rodriguez, Brian P. Griffin, Donald R. Neumann, Raymundo T. Go, James D. Thomas, Miguel Ares, Mario J. Garcia |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty chemistry.chemical_element Coronary Disease Coronary Angiography Sensitivity and Specificity Computed tomographic Coronary artery disease Coronary Circulation Internal medicine Image Processing Computer-Assisted medicine Humans In patient cardiovascular diseases Aged Tomography Emission-Computed Single-Photon Chi-Square Distribution business.industry Middle Aged medicine.disease Coronary heart disease body regions Radiation exposure Thallium Radioisotopes chemistry Exercise Test cardiovascular system Cardiology Thallium Female Tomography Cardiology and Cardiovascular Medicine Nuclear medicine business Perfusion |
| Zdroj: | The American Journal of Cardiology. 74:977-981 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(94)90843-5 |
| Popis: | Thallium reinjection can improve the detection of severely ischemic viable myocardium in patients with coronary artery disease. However, a disadvantage of this method is that it requires the acquisition of 3 separate sets of images and the administration of an additional dose of the radiotracer. Alternatively, quantitative analysis of the regional myocardial washout of thallium-201 can be easily obtained from the conventional postexercise and redistribution images without additional imaging time or radiation exposure to the patient. To determine whether this method can predict the results of thallium reinjection, this study analyzed thallium-201 images of 31 patients who had persistent perfusion defects in qualitative exercise/delayed redistribution single-photon emission computed tomographic thallium studies and who underwent thallium reinjection. The quantitative mean radioactive counts of each myocardial segment that had a persistent perfusion defect in the initial and delayed redistribution on 4-hour short-axis tomographic slices were measured to derive a delayed/initial ratio, and these values were compared with the results of thallium reinjection. The delayed/initial ratio was 1.06 +/- 0.22 in 39 segments that improved, versus 0.58 +/- 0.18 in 43 segments without improvement after reinjection (p0.001). Thirty-eight of the 39 segments that improved had a ratio ofor = 0.75, versus only 3 of the 43 segments that showed no improvement (sensitivity, 98%; specificity, 91%). The correlation between the delayed/initial ratio and reinjection results was equally high at any segment location or severity. It is concluded that quantitative regional thallium washout analysis predicts the results of thallium reinjection in segments with persistent thallium defects.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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