Crystalloid fluid suspension results in decreased adhesion burden when compared to bioresorbable membranes in a rat model
| Autor: | Joseph P. Kononchik, Kevin R. Kniery, John Kuckelman, Morgan R. Barron, Zachary S. Hoffer, Vance Y. Sohn, Jeffrey T. Kay |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Rat model Urology Neovascularization Physiologic Pilot Projects Tissue Adhesions Rats Sprague-Dawley Abdominal wall Random Allocation 03 medical and health sciences Cecum 0302 clinical medicine Suspensions Absorbable Implants medicine Animals Prospective Studies Adhesion prevention Hyaluronic Acid Saline Abdominal adhesions business.industry Abdominal Wall Membranes Artificial General Medicine Adhesion Abdominal adhesion medicine.anatomical_structure 030220 oncology & carcinogenesis Models Animal 030211 gastroenterology & hepatology Surgery Saline Solution business |
| Zdroj: | The American Journal of Surgery. 217:954-958 |
| ISSN: | 0002-9610 |
| Popis: | Introduction Adhesion formation represents a major cause of long-term morbidity. Suspension of intra-abdominal contents in fluid medium may effectively prevent adhesion formation. We compare saline hydro-flotation (NS) to hyaluronate bioresorbable membranes (HBM) for adhesion prevention following surgery. Methods Animals were randomized to four groups: sham (no injury, n = 5), control (injury without intervention, n = 5), HBM (n = 20) or 10 cc NS (n = 21). Interventions were administered after standardized surgical trauma to the cecum and abdominal wall. Necropsies at two weeks were completed to compare adhesion burden using a customary scoring algorithm. Results Significant adhesion burden was noted in all rats. HBM sustained a more significant adhesion burden with higher total adhesion scores (HBM = 10 vs NS = 8.1/15, p = 0.02). Gross adhesion scores were lower with NS (5.6/9) compared to HBM (7.1/9, p = 0.01). Neo-vascularity was more common in HBM at 2.6/3 versus 1.9/3 with NS (p = 0.01). Percent of the cecum encased with adhesion was higher with HBM (42%) compared to NS (31%, p = 0.05). Discussion Fluid based anti-adhesion methods should be considered for abdominal adhesion formation prevention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect