Hypertrophic Scars and Keloids—A Review of Their Pathophysiology, Risk Factors, and Therapeutic Management

Autor:	Dolores Wolfram, Hildegunde Piza-Katzer, Alexandar Tzankov, Petra Pülzl
Rok vydání:	2009
Předmět:	Wound Healing medicine.medical_specialty Cicatrix Hypertrophic business.industry Optimal treatment Dermatology General Medicine Tissue repair Pathophysiology Surgery Risk Factors Keloid Animals Humans Medicine Hypertrophic scars skin and connective tissue diseases business Wound healing
Zdroj:	Dermatologic Surgery. 35:171-181
ISSN:	1076-0512
DOI:	10.1111/j.1524-4725.2008.34406.x
Popis:	BACKGROUND Hypertrophic scars and keloids result from an abnormal fibrous wound healing process in which tissue repair and regeneration-regulating mechanism control is lost. These abnormal fibrous growths present a major therapeutic dilemma and challenge to the plastic surgeon because they are disfiguring and frequently recur. OBJECTIVE To provide updated clinical and experimental information on hypertrophic scars and keloids so that physicians can better understand and properly treat such lesions. METHODS A Medline literature search was performed for relevant publications and for diverse strategies for management of hypertrophic scars and keloids. CONCLUSION The growing understanding of the molecular processes of normal and abnormal wound healing is promising for discovery of novel approaches for the management of hypertrophic scars and keloids. Although optimal treatment of these lesions remains undefined, successful healing can be achieved only with combined multidisciplinary therapeutic regimens.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270c81afbca0360083da99ccaeb21c1c https://doi.org/10.1111/j.1524-4725.2008.34406.x Zobrazit plný text záznamu Plný text