Nanodroplet-Vaporization-Assisted Sonoporation for Highly Effective Delivery of Photothermal Treatment
| Autor: | Pai-Chi Li, Ya-Chuen Yang, Yu-Ren Liou, C. R. Chris Wang, Shu-Wei Liu, Wei-Wen Liu, Yu-Hsun Wu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell Membrane Permeability Materials science Cell Survival Sonication 02 engineering and technology Article 03 medical and health sciences In vivo Vaporization Nanotechnology Microbubbles Multidisciplinary business.industry Ultrasound Photothermal therapy 021001 nanoscience & nanotechnology 030104 developmental biology Cavitation Nanoparticles Volatilization 0210 nano-technology business Sonoporation Biomedical engineering |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep24753 |
| Popis: | Sonoporation refers to the use of ultrasound and acoustic cavitation to temporarily enhance the permeability of cellular membranes so as to enhance the delivery efficiency of therapeutic agents into cells. Microbubble-based ultrasound contrast agents are often used to facilitate these cavitation effects. This study used nanodroplets to significantly enhance the effectiveness of sonoporation relative to using conventional microbubbles. Significant enhancements were demonstrated both in vitro and in vivo by using gold nanorods encapsulated in nanodroplets for implementing plasmonic photothermal therapy. Combined excitation by ultrasound and laser radiation is used to trigger the gold nanodroplets to induce a liquid-to-gas phase change, which induces cavitation effects that are three-to-fivefold stronger than when using conventional microbubbles. Enhanced cavitation also leads to significant enhancement of the sonoporation effects. Our in vivo results show that nanodroplet-vaporization-assisted sonoporation can increase the treatment temperature by more than 10 °C above that achieved by microbubble-based sonoporation. |
| Databáze: | OpenAIRE |
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