Comparison of Effects of Dexmedetomidine-ketamine and Dexmedetomidine-midazolam Combinations in Transurethral Procedures
| Autor: | Alpaslan Apan, Ertan Batislam, Erdal Yilmaz, Emine Arzu Kose, Mehtap Honca |
|---|---|
| Přispěvatelé: | Kırıkkale Üniversitesi |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Mean arterial pressure medicine.medical_specialty Visual analogue scale Nausea Urology Sedation Conscious Sedation Blood Pressure Double-Blind Method Urethra Adrenergic alpha-2 Receptor Agonists medicine Humans Ketamine Prospective Studies Dexmedetomidine Analgesics business.industry Hemodynamics Middle Aged Surgery Drug Combinations Anesthesia Vomiting Urologic Surgical Procedures Midazolam Female medicine.symptom business medicine.drug |
| Zdroj: | Urology. 79:1214-1219 |
| ISSN: | 0090-4295 |
| Popis: | Batislam, Ertan/0000-0002-7493-4573 WOS: 000304720600012 PubMed: 22656405 OBJECTIVE To compare the effects of dexmedetomidine-ketamine and dexmedetomidine-midazolam combinations on the recovery time, hemodynamic and respiratory variables, and side effects in patients undergoing transurethral procedures. METHODS Sixty patients scheduled for elective outpatient transurethral procedure were randomized into 2 groups. In the group K, a ketamine-dexmedetomidine combination was administered, and in the group M, midazolam-dexmedetomidine was administered, to provide sedation/analgesia. Pain and sedation levels were assessed using visual analog score (VAS) and Ramsey Sedation Scale, respectively. The recovery time was assessed with the scale of Aldrete. Time was measured and recorded to the moment at which patient responses brought the Aldrete score to 10 points. Time to eye opening and length of stay in the recovery room were recorded. RESULTS Group M showed significantly lower mean arterial pressure (MAP) values at 5 and 10 minutes during the procedure when compared with group K (P = .02 and P = .01, respectively). Visual analogue scale scores were greater in group M than in group K at 5 and 10 minutes for the transurethral procedure (P = .039 and P = .028, respectively). Sedation scores were similar between groups during the procedure. Time to eye opening and length of recovery room stay were shorter (P < .001 and P < .001, respectively), and Aldrete scores were greater in group K than group M. CONCLUSION Both combinations provided satisfactory sedation levels, but the dexmedetomidine-ketamine combination provided better analgesia and hemodynamic stability, with less nausea and vomiting and shorter recovery time, than the dexmedetomidine-midazolam combination. UROLOGY 79: 1214-1219, 2012. (c) 2012 Elsevier Inc. |
| Databáze: | OpenAIRE |
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