The combined and individual impact of diabetes and smoking on key subgingival periodontal pathogens in patients with chronic periodontitis
| Autor: | L. C. Figueiredo, Tamires Szeremeske Miranda, M. Feres, Claudia Regina Joaquim, Letícia Macedo Marins, H. D. P. Silva, Poliana Mendes Duarte |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Oral Hygiene Index Bleeding on probing Dental Plaque Gingiva Dentistry Gastroenterology Diabetes Complications 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Tannerella forsythia Medicine Humans Periodontal Pocket Aged Periodontitis biology Bacteria business.industry Eubacterium nodatum Microbiota Smoking Prevotella intermedia Treponema denticola 030206 dentistry Middle Aged biology.organism_classification medicine.disease Chronic periodontitis stomatognathic diseases 030104 developmental biology Diabetes Mellitus Type 2 Biofilms Chronic Periodontitis Periodontics Female Fusobacterium nucleatum medicine.symptom business |
| Zdroj: | Journal of periodontal research. 53(3) |
| ISSN: | 1600-0765 |
| Popis: | Background and Objective Comprehension of the similarities and differences in the composition of the subgingival microbiota of patients with diabetes mellitus (DM), smokers or smokers with DM is an important step in developing therapies specific for these groups at risk for periodontitis. Therefore, the aim of this study was to compare the combined and individual effects of DM and smoking on the levels and prevalence of key subgingival periodontal pathogens in patients with chronic periodontitis. Material and Methods One hundred patients with generalized chronic periodontitis were allocated into one of the following groups: DM (n = 25, non-smokers with type 2 DM); S (n = 25, non-diabetic smokers); SDM (n = 25, smokers with type 2 DM); and control (n = 25, non-diabetic non-smokers). Two subgingival biofilm samples from healthy sites (probing depth and clinical attachment level ≤3 mm and no bleeding) and 2 from diseased sites (probing depth and clinical attachment level ≥5 mm and bleeding on probing) were analyzed by quantitative polymerase chain reaction for Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Eubacterium nodatum, Parvimonas micra, Fusobacterium nucleatum ssp. and Prevotella intermedia. Results There were no differences among groups in the mean counts of the bacterial species studied, considering all sampled sites (healthy plus diseased sites). There were also no differences among groups regarding the prevalence of any bacteria species in healthy and diseased sites (P > .05). The mean P. micra count was significantly higher in the healthy sites of both smoking groups, than in those of the control group (P |
| Databáze: | OpenAIRE |
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