Gemcitabine and carboplatin treatment in advanced NSCLC: a retrospective evaluation including elderly patients
| Autor: | Davide Boy, Matteo Vallauri, Roberto Murialdo, Lorenza Moraglio, Lucia Tixi, Giorgio Sogno, Isabella Angelini, Fulvio Brema, Francesca Bertolotti, Alberto Ballestrero, Vittoria Saccà, Gisella Pastorino, Maria Cristina Martini |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms Nausea Anemia medicine.medical_treatment Kaplan-Meier Estimate Deoxycytidine Disease-Free Survival 030218 nuclear medicine & medical imaging Carboplatin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Carcinoma Non-Small-Cell Lung Antineoplastic Combined Chemotherapy Protocols medicine Humans Aged Retrospective Studies Aged 80 and over Chemotherapy business.industry Cancer General Medicine Middle Aged medicine.disease Gemcitabine Regimen chemistry 030220 oncology & carcinogenesis Vomiting Female medicine.symptom business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0300-8916 |
| Popis: | Background Carboplatin-containing regimens are sometimes preferred for patients with advanced non-small cell lung cancer. Methods Eighty-three patients with stage III-IV non-small cell lung cancer received 3 to 4 cycles of carboplatin AUC 5 on day 2 and gemcitabine 1250 mg/m2 on days 1 and 8 every 21 days. Results The overall response rate was 43.4%. Results obtained from elderly and non-elderly groups were compared using the logrank method. Median overall survival and progression-free survival were 11 and 7 months, respectively (12 and 7 months, non-elderly group; 6.5 and 5 months, elderly group, P = 0.28 and 0.25 respectively). Grade 3–4 toxicity included neutropenia, thrombocytopenia, anemia, nausea/vomiting, and diarrhea. Incidences of grade 3–4 toxicity were similar for elderly and non-elderly patients. Conclusions Data confirm that carboplatin-gemcitabine is an active and well-tolerated regimen in advanced non-small cell lung cancer and could be investigated in elderly patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|