The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling
| Autor: | Nobuko Ohashi, Martha B. Ramírez-Rosas, Yuya Fujita, Juan Miguel Jimenez-Andrade, Sarah A. Woller, Gilson Gonçalves dos Santos, Enriqueta Muñoz-Islas, Glaucilene F. Catroli, Maripat Corr, Tony L. Yaksh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Knee Joint lcsh:Medicine Arthritis Neurodegenerative Transgenic Nociceptive Pain Mice 0302 clinical medicine Ganglia Spinal 2.1 Biological and endogenous factors Aetiology Nerve Tissue lcsh:Science Analgesics Multidisciplinary Microglia Pain Research Chronic pain medicine.anatomical_structure Phenotype Hyperalgesia Sensory processing Female Chronic Pain medicine.symptom Gabapentin medicine.drug Genetically modified mouse medicine.medical_specialty Spinal Inflammation Mice Transgenic Calcitonin gene-related peptide Autoimmune Disease Article 03 medical and health sciences Experimental Rheumatology Internal medicine medicine Animals Peripheral Neuropathy 030203 arthritis & rheumatology ATF3 business.industry lcsh:R Neurosciences medicine.disease Arthritis Experimental Endocrinology nervous system Neuralgia lcsh:Q Ganglia business 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Scientific Reports Scientific reports, vol 10, iss 1 Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) |
| ISSN: | 2045-2322 |
| Popis: | The adult K/BxN transgenic mouse develops spontaneous autoimmune arthritis with joint remodeling and profound bone loss. We report that both males and females display a severe sustained tactile allodynia which is reduced by gabapentin but not the potent cyclooxygenase inhibitor ketorolac. In dorsal horn, males and females show increased GFAP+ astrocytic cells; however, only males demonstrate an increase in Iba1+ microglia. In dorsal root ganglia (DRG), there is an increase in CGRP+, TH+, and Iba1+ (macrophage) labeling, but no increase in ATF3+ cells. At the ankle there is increased CGRP+, TH+, and GAP-43+ fiber synovial innervation. Thus, based on the changes in dorsal horn, DRG and peripheral innervation, we suggest that the adult K/BxN transgenic arthritic mice display a neuropathic phenotype, an assertion consistent with the analgesic pharmacology seen in this animal. These results indicate the relevance of this model to our understanding of the nociceptive processing which underlies the chronic pain state that evolves secondary to persistent joint inflammation. |
| Databáze: | OpenAIRE |
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