Pregnancy outcomes following 24-chromosome preimplantation genetic diagnosis in couples with balanced reciprocal or Robertsonian translocations

Autor: N. Wemmer, Ruth B. Lathi, J. Mash, B. Pettersen, Dennis Idowu, D. Kijacic, Katrina Merrion
Rok vydání: 2015
Předmět:
Zdroj: Fertility and Sterility. 103:1037-1042
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2014.12.118
Popis: Objective To report live birth rates (LBR) and total aneuploidy rates in a series of patients with balanced translocations who pursued in vitro fertilization (IVF)–preimplantation genetic diagnosis (PGD) cycles. Design Retrospective cohort analysis. Setting Genetic testing reference laboratory. Patient(s) Seventy-four couples who underwent IVF-PGD due to a parental translocation. Intervention(s) IVF cycles and embryo biopsies were performed by referring clinics. Biopsy samples were sent to a single reference lab for PGD for the translocation plus 24-chromosome aneuploidy screening with the use of a single-nucleotide polymorphism (SNP) microarray. Main Outcome Measure(s) LBR per biopsy cycle, aneuploidy rate, embryo transfer (ET) rate, miscarriage rate. Result(s) The LBR per IVF biopsy cycle was 38%. LBR for patients reaching ET was 52%. Clinical miscarriage rate was 10%. Despite a mean age of 33.8 years and mean of 7 embryos biopsied, there was a 30% chance for no chromosomally normal embryos. Maternal age >35 years, day 3 biopsy, and having fewer than five embryos available for biopsy increased the risk of no ET. Conclusion(s) IVF-PGD for translocation and aneuploidy screening had good clinical outcomes. Patients carrying a balanced translocation who are considering IVF-PGD should be aware of the high risk of no ET, particularly in women ≥35 years old.
Databáze: OpenAIRE