Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Apparently Uncomplicated Type 2 Diabetic Patients
| Autor: | Carmine Gazzaruso, Adriana Garzaniti, Diego Geroldi, Gianandrea Bertone, Stefano Giordanetti, Emanuela De Amici, Sebastiano Bruno Solerte, Colomba Falcone, Pietro Fratino |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Myocardial Ischemia Coronary Artery Disease Asymptomatic Coronary artery disease Erectile Dysfunction Polymorphism (computer science) Physiology (medical) Diabetes mellitus Internal medicine Prevalence medicine Stress Echocardiography Humans cardiovascular diseases biology business.industry Middle Aged medicine.disease Surgery Radiography Erectile dysfunction Diabetes Mellitus Type 2 biology.protein Cardiology Microalbuminuria medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 110:22-26 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.0000133278.81226.c9 |
| Popis: | Background— Erectile dysfunction (ED) is associated with coronary artery disease (CAD). In diabetic patients, CAD is often silent. Among diabetic patients with silent CAD, the prevalence of ED has never been evaluated. We investigated whether ED is associated with asymptomatic CAD in type 2 diabetic patients. Methods and Results— We evaluated the prevalence of ED in 133 uncomplicated diabetic men with angiographically verified silent CAD and in 127 diabetic men without myocardial ischemia at exercise ECG, 48-hour ambulatory ECG, and stress echocardiography. The groups were comparable for age and diabetes duration. Patients were screened for ED using the validated International Index of Erectile Function (IIEF-5) questionnaire. The prevalence of ED was significantly higher in patients with than in those without silent CAD (33.8% versus 4.7%; P =0.000). Multiple logistic regression analysis showed that ED, apolipoprotein(a) polymorphism, smoking, microalbuminuria, HDL, and LDL were significantly associated with silent CAD; among these risk factors, ED appeared to be the most efficient predictor of silent CAD (OR, 14.8; 95% CI, 3.8 to 56.9). Conclusions— Our study first shows a strong and independent association between ED and silent CAD in apparently uncomplicated type 2 diabetic patients. If our findings are confirmed, ED may become a potential marker to identify diabetic patients to screen for silent CAD. Moreover, the high prevalence of ED among diabetics with silent CAD suggests the need to perform an exercise ECG before starting a treatment for ED, especially in patients with additional cardiovascular risk factors. |
| Databáze: | OpenAIRE |
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