Specific memory and sedative effects of the benzodiazepine triazolam
| Autor: | Eileen M. Joyce, Richard G. Lister, T. George, Herbert Weingartner, Michael J. Eckardt, C.M. Adams, Karen Y. Sirocco |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Benzodiazepine Triazolam medicine.drug_class 05 social sciences Impaired memory medicine.disease 050105 experimental psychology 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Flumazenil Sedative Anesthesia Explicit memory medicine 0501 psychology and cognitive sciences Pharmacology (medical) Memory disorder Implicit memory Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of psychopharmacology (Oxford, England). 7(4) |
| ISSN: | 0269-8811 |
| Popis: | Fifteen normal volunteers were administered placebo, 0.250, 0.375 and 0.500 mg of triazolam in a double- blind cross-over design. Triazolam induced robust dose-dependent impairments in explicit memory of information presented after drug administration. Subjects were unaware of their memory deficit (an impairment in meta-cognition). In contrast, memory for information presented prior to the administration of triazolam was facilitated following the administration of low doses of triazolam. Implicit memory and access to knowledge memory was unaltered by this benzodiazepine. An analysis of these results controlling for concurrent sedation as measured subjectively, through the use of self rating scales and objectively, based upon psychomotor performance, demonstrated that the amnestic effects of triazolam are largely independent of sedative effects. The pattern of memory changes induced by benzodiazepines, such as triazolam, is similar to the memory inpairment expressed in amnestic patients but unlike the pattern of impaired memory evident in dementia such as Alzheimer's disease. |
| Databáze: | OpenAIRE |
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