Magnoliae Flos Essential Oil as an Immunosuppressant in Dendritic Cell Activation and Contact Hypersensitivity Responses
| Autor: | Hsin-Chun Chen, Wen-Te Chang, Meng-Shiou Lee, Yi-Chen Liu, Ming-Kuem Lin, Chun-Hsien Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
T-Lymphocytes
Flos Adaptive Immunity Nasal congestion Dermatitis Contact Magnoliaceae law.invention Mice 03 medical and health sciences 0302 clinical medicine law Oils Volatile Animals Medicine Sinusitis Cells Cultured Essential oil 030304 developmental biology 0303 health sciences Eucalyptol biology business.industry Contact hypersensitivity Dendritic Cells General Medicine Dendritic cell medicine.disease biology.organism_classification Camphor Disease Models Animal Complementary and alternative medicine 030220 oncology & carcinogenesis Immunology Cytokines medicine.symptom business Immunosuppressive Agents Phytotherapy |
| Zdroj: | The American Journal of Chinese Medicine. 48:597-613 |
| ISSN: | 1793-6853 0192-415X |
| DOI: | 10.1142/s0192415x20500305 |
| Popis: | Magnoliae Flos is a commonly used traditional medicinal material in Asia. It is used to treat sinusitis, nasal congestion, and hypersensitive skin. Because Magonlia Flos was described as an aromatic material in ancient Chinese texts, we hypothesized that its essential oil may be used to treat immune disorders. Dendritic cells (DCs), regarded as a major target of immunomodulators to control immune responses, play a critical role in the adaptive immune response. In this study, Magnoliae Flos essential oil (MFEO) decreased the production of the cytokines TNF-[Formula: see text], IL-6, and IL-12p70 in lipopolysaccharide (LPS)-stimulated DCs. It also suppressed the surface markers MHC II, CD80, and CD86 in LPS-stimulated DCs. Animal models demonstrated that the 2,4-Dinitro-1-fluorobenzene (DNFB) inducing a contact hypersensitivity response was inhibited following treatment with MFEO. In addition, MFEO inhibited the infiltration of T cells in the ears of DNFB-induced mice. To explore its bioactive compounds, the components of MFEO were analyzed using gas chromatography (GC) and GC-mass spectrometry. The results revealed that the major compounds in MFEO are camphor and 1,8-cineole. Additional DC bioassays confirmed that these compounds substantially suppressed cytokine production in LPS-induced DCs. Therefore, we demonstrated that MFEO exhibits an immunosuppressive effect both in vivo and in vitro, and camphor and 1,8-cineole may be the major components responsible for its immunosuppressive ability. The findings indicate that MFEO has the potential to be developed as a new immunosuppressant for excessive diseases. |
| Databáze: | OpenAIRE |
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