Serovar D and E of serogroup B induce highest serological responses in urogenital Chlamydia trachomatis infections
| Autor: | P. M. Oostvogel, P. Joep Dörr, Caroline J. Bax, Sander Ouburg, Koen D. Quint, Stephan P. Verweij, Servaas A. Morré, E. Lanjouw, Remco P. H. Peters, Henry J. C. de Vries, J. Pleijster |
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| Přispěvatelé: | Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Dermatology, Genetica & Celbiologie, RS: GROW - Developmental Biology, Institute for Public Health Genomics, RS: GROW - R4 - Reproductive and Perinatal Medicine, Medical Microbiology and Infection Prevention, Obstetrics and gynaecology, CCA - Immuno-pathogenesis |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Serotype medicine.medical_specialty Genotype IgG Enzyme-Linked Immunosorbent Assay Chlamydia trachomatis medicine.disease_cause Serogroup Antibodies Serology Medical microbiology Male Urogenital Diseases Prevalence medicine Humans Serological response Genotyping Netherlands biology business.industry Serovar Chlamydia Infections Female Urogenital Diseases Titer Infectious Diseases Immunology biology.protein Population study Female Antibody business Research Article |
| Zdroj: | BMC Infectious Diseases, 14 BMC infectious diseases, 14(1). BioMed Central BMC Infectious Diseases, 14:3. BioMed Central Ltd BMC Infectious Diseases Verweij, S P, Lanjouw, E, Bax, C J, Quint, K D, Oostvogel, P M, Dorr, P J, Pleijster, J, de vries, H J C, Peters, R P H, Ouburg, S & Morré, S A 2014, ' Serovar D and E of serogroup B induce highest serological responses in urogenital Chlamydia trachomatis infections ', BMC Infectious Diseases, vol. 14, 3 . https://doi.org/10.1186/1471-2334-14-3 BMC Infectious Diseases, 14:3. BioMed Central |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/1471-2334-14-3 |
| Popis: | Background Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection (STI) worldwide. A strong link between C. trachomatis serogroup/serovar and serological response has been suggested in a previous preliminary study. The aim of the current study was to confirm and strengthen those findings about serological IgG responses in relation to C. trachomatis serogroups and serovars. Methods The study population (n = 718) consisted of two patient groups with similar characteristics of Dutch STI clinic visitors. We performed genotyping of serovars and used titre based and quantitative commercially available ELISA kits (medac Diagnostika) to determine specific serum IgG levels. Optical density (OD) values generated by both tests were used to calculate the IgG titres (cut-off 1:50). Analyses were conducted stratified by gender. Results We observed very significant differences when comparing the median IgG titres of three serogroups, B, C and I: in women for B vs. C: p |
| Databáze: | OpenAIRE |
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