Pathological factors associated with non‐sentinel lymph node metastasis in early stage cervical cancer
| Autor: | Thiago Pereira Diniz, Bruna Tirapelli Gonçalves, Andrea Paiva Gadelha Guimarães, Lillian Yuri Kumagai, Louise De Brot, Carlos Chaves Faloppa, A. Menezes, Alexandre Andre Balieiro Anastacio da Costa, Levon Badiglian-Filho, Glauco Baiocchi, Henrique Mantoan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Sentinel lymph node Uterine Cervical Neoplasms Hysterectomy Metastasis Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Stage (cooking) Lymph node Aged Neoplasm Staging Retrospective Studies Cervical cancer Sentinel Lymph Node Biopsy Parametrial business.industry General Medicine Middle Aged medicine.disease body regions medicine.anatomical_structure Oncology Neoplasm Micrometastasis 030220 oncology & carcinogenesis Lymph Node Excision Immunohistochemistry Female 030211 gastroenterology & hepatology Surgery Lymphadenectomy Lymph Nodes Radiology Sentinel Lymph Node business Follow-Up Studies |
| Zdroj: | Journal of Surgical Oncology. 123:1115-1120 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.26341 |
| Popis: | Objective To analyze the predictive factors for non-sentinel lymph node (non-SLN) metastasis in early-stage cervical cancer. Methods We analyzed a series of 113 patients who underwent sentinel lymph node (SLN) mapping for cervical cancer. The SLNs were examined by immunohistochemistry (IHC) when the hematoxylin-eosin stain was negative. Results The overall bilateral detection rate was 81.5%, with a median of two SLNs resected. The study ultimately included 92 patients with SLNs that were mapped who had also undergone systematic pelvic lymph node dissection. Thirteen (14.1%) patients had positive SLNs, with a median of one positive SLN. Regarding the size of SLN metastasis, one (1.1%) had isolated tumor cells (ITC), seven (7.6%) had micrometastases, and five (5.4%) had macrometastases. Notably, 46.1% (6/13) had lymph node metastases detected only after IHC. Five (38.5%) cases had positive non-SLNs, with a median count of one positive lymph node. Parametrial invasion was the only risk factor for positive non-SLN (p = .045). Regarding the size of SLN metastasis, non-SLN involvement was present in the only case with ITC (1/1), 42.9% (3/7) of cases with micrometastases, and in 20% (1/5) with macrometastases. Conclusions Our data suggest that parametrial invasion correlates with the risk of non-SLN metastasis in cervical cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text