The Italian START-Register on anticoagulation with focus on atrial fibrillation
| Autor: | Antonucci, E, Poli, D, Tosetto, A, Pengo, V, Tripodi, A, Magrini, N, Marongiu, F, Palareti, G, Testa, S, Paoletti, O, Falanga, A, Lerede, T, Guazzaloca, G, Marcucci, R, Piana, A, Cibecchini, F, Ruocco, L, Lucarelli, G, Paparo, C, Martini, G, Scovoli, G, Bradamante, S, Malcangi, G, Lombardi, M, Insana, A, Toma, A, Barbera, P, Masciocco, L, Saracino, P, Benvenuto, A, Vasselli, C, Sangiorgio, R, Crippa, L, Pedrini, S, Bertola, F, Rupoli, S, Lion,e D, Pasca, S, Roldan, V, Rossi, V, Bucherini, E, Gresele, P, Mangione C, Cicconi, S, Casasco, P, Castaman, G, Liberato, NL, Bendotti, C, Oriana, V, Manotti, P, Zighetti, ML, Pedico, P, Fidone, E, Lombardo, C, Paci, OO, Pezzella, S, Pezzo, M, Ciampa, A, Maccaroni, I, Molini, G, Ciardiello, A, Marietta, M, Turrini, A, Barcellona, D |
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| Přispěvatelé: | Antonucci, E, Poli, D, Tosetto, A, Pengo, V, Tripodi, A, Magrini, N, Marongiu, F, Palareti, G, Testa, S, Paoletti, O, Falanga, A, Lerede, T, Guazzaloca, G, Marcucci, R, Piana, A, Cibecchini, F, Ruocco, L, Lucarelli, G, Paparo, C, Martini, G, Scovoli, G, Bradamante, S, Malcangi, G, Lombardi, M, Insana, A, Toma, A, Barbera, P, Masciocco, L, Saracino, P, Benvenuto, A, Vasselli, C, Sangiorgio, R, Crippa, L, Pedrini, S, Bertola, F, Rupoli, S, Lion, E, Pasca, S, Roldan, V, Rossi, V, Bucherini, E, Gresele, P, Mangione, C, Cicconi, S, Casasco, P, Castaman, G, Liberato, N, Bendotti, C, Oriana, V, Manotti, P, Zighetti, M, Pedico, P, Fidone, E, Lombardo, C, Paci, O, Pezzella, S, Pezzo, M, Ciampa, A, Maccaroni, I, Molini, G, Ciardiello, A, Marietta, M, Turrini, A, Barcellona, D |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Genetics and Molecular Biology (all)
Male medicine.medical_specialty lcsh:Medicine Renal function Hemorrhage Biochemistry Atrial Fibrillation coagulation anticoagulation Cohort Studies chemistry.chemical_compound Interquartile range Risk Factors Internal medicine Atrial Fibrillation medicine 80 and over Humans Registries Renal Insufficiency lcsh:Science Stroke Aged Aged 80 and over Creatinine Multidisciplinary business.industry Anticoagulants Female Italy Middle Aged Medicine (all) lcsh:R Atrial fibrillation medicine.disease Surgery Clinical trial Agricultural and Biological Sciences (all) chemistry Biochemistry Genetics and Molecular Biology (all) lcsh:Q Observational study business Research Article Cohort study |
| Zdroj: | PLoS ONE, Vol 10, Iss 5, p e0124719 (2015) PLoS ONE |
| Popis: | START-Register - Survey on anTicoagulated pAtients RegisTer - is an independent, inception-cohort, observational, collaborative database aimed at recording prospectively the clinical history of adult patients starting anticoagulant treatment for any reason and using whatever drug. In this article we present the START-Register and give cross section baseline data focusing on non valvular atrial fibrillation (NVAF). Participants are asked to insert prospectively consecutive patients recorded as electronic file on the web-site of the registry. Required data are: demographic and clinical characteristics of patients, associated risk factors for stroke and bleeding, laboratory routine data, clinical indication for treatment, expected therapeutic range (in cases of treatment with vitamin K antagonists -VKAs). The follow-up is carried out to record: quality of treatment (for patients on VKAs), bleeding complications, thrombotic events, and the onset of any type of associated disease. To date 5252 patients have been enrolled; 97.6% were on VKAs because direct oral anticoagulants (DOAC) have been available in Italy only recently. The median age was 74 years [interquartile range (IQR) 64-80]; males 53.7%. This analysis is focused on the 3209 (61.1%) NVAF patients. Mean CHADS2 score was 2.1±1.1, CHADSVASc score was 3.1±1.3;median age was 76 years (IQR 70-81); 168 patients (5.3%) had severe renal failure [Creatinine clearance (CrCl) 80 years with high prevalence of renal failure. |
| Databáze: | OpenAIRE |
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