In vivo histocompatibility evaluation of polyurethane membrane modified by superfine silk-fibroin powder
| Autor: | Weici Wang, Hongjun Yang, Weilin Xu, Chenxi Ouyang, Haiye Xu |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Materials science
Scanning electron microscope Polyurethanes Biomedical Engineering Fibroin Biocompatible Materials Biochemistry Biomaterials Mice Random Allocation chemistry.chemical_compound Implants Experimental In vivo Genetics Animals Muscle Skeletal Earth-Surface Processes Polyurethane Polytetrafluoroethylene fungi technology industry and agriculture Biomaterial Membranes Artificial Membrane chemistry Chemical engineering Transmission electron microscopy Vascular Grafting Powders Fibroins |
| Zdroj: | Journal of Huazhong University of Science and Technology [Medical Sciences]. 29:508-511 |
| ISSN: | 1993-1352 1672-0733 |
| DOI: | 10.1007/s11596-009-0423-7 |
| Popis: | In this study, a novel polyurethane membrane, modified by superfine silk-fibroin powder, was prepared for small-diameter vascular grafting. Scanning electron microscopy, transmission electron microscopy, and histological examination were applied to evaluate histocompatibility of this polyurethane membrane. The polyurethane membrane was compared with polytetrafluoroethylene material. A pseudomembrane and gap formed between polytetrafluoroethylene and the surrounding tissues, and no cells infiltrated or grew into the polytetrafluoroethylene material. On the contrary, superfine silk-fibroin powder/polyurethane blend membrane merged tightly with the surrounding tissues without gaps, and cells infiltrated and grew into the material. Moreover, the negative effects of superfine silk-fibroin powder/polyurethane blend membrane on cells were less than those of its polytetrafluoroethylene counterpart. Our findings indicated that the superfine silk-fibroin powder/polyurethane blend membrane has better histocompatibility than polytetrafluoroethylene membrane. It is concluded that the superfine silk-fibroin powder/polyurethane blend membrane is a promising biomaterial for small-diameter prosthesis. |
| Databáze: | OpenAIRE |
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