Integrins as Therapeutic Targets for Respiratory Diseases
| Autor: | S. S.L. Tan, Thai Tran, Chun Ming Teoh |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Integrins
lung disease Cell Survival Respiratory Tract Diseases Integrin Biology Biochemistry Article Extracellular matrix Cell Movement Transforming Growth Factor beta Pulmonary fibrosis Cell Adhesion medicine Animals Humans Osteonectin Molecular Targeted Therapy sarcoidosis Cell adhesion Receptor Lung Molecular Biology Mice Knockout Clinical Trials as Topic Neovascularization Pathologic pulmonary fibrosis General Medicine Transforming growth factor beta medicine.disease Asthma Transmembrane protein Extracellular Matrix Cell biology Disease Models Animal lung cancer Phenotype Treatment Outcome emphysema Gene Expression Regulation Multigene Family biology.protein Airway Remodeling Molecular Medicine Signal transduction Carrier Proteins Protein Binding Signal Transduction |
| Zdroj: | Current Molecular Medicine |
| ISSN: | 1566-5240 |
| DOI: | 10.2174/1566524015666150921105339 |
| Popis: | Integrins are a large family of transmembrane heterodimeric proteins that constitute the main receptors for extracellular matrix components. Integrins were initially thought to be primarily involved in the maintenance of cell adhesion and tissue integrity. However, it is now appreciated that integrins play important roles in many other biological processes such as cell survival, proliferation, differentiation, migration, cell shape and polarity. Lung cells express numerous combinations and permutations of integrin heterodimers. The complexity and diversity of different integrin heterodimers being implicated in different lung diseases present a major challenge for drug development. Here we provide a comprehensive overview of the current knowledge of integrins from studies in cell culture to integrin knockout mouse models and provide an update of results from clinical trials for which integrins are therapeutic targets with a focus on respiratory diseases (asthma, emphysema, pneumonia, lung cancer, pulmonary fibrosis and sarcoidosis). |
| Databáze: | OpenAIRE |
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