World Health Organization International Standards for highly purified human, porcine and bovine insulins
| Autor: | A.F. Bristow, R.E. Gaines Das, D. R. Bangham |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Swine medicine.medical_treatment education Radioimmunoassay Pharmacology World Health Organization General Biochemistry Genetics and Molecular Biology World health Internal medicine medicine Animals Humans Insulin Reference standards health care economics and organizations business.industry INSULIN PREPARATIONS Reference Standards Endocrinology Calibration Biological Assay Cattle Drug Contamination business |
| Zdroj: | Journal of Biological Standardization. 16:165-178 |
| ISSN: | 0092-1157 |
| Popis: | The 4th International Standard (IS) for Insulin, established in 1958, consists of a mixture of relatively impure bovine and porcine insulins and is not suitable as a standard for the assay of highly purified single-species insulins presently used in the treatment of diabetes. Preparations of human, bovine and porcine crystalline insulins, representative of current highly purified therapeutic insulins, have now been studied in an international collaborative study carried out by twenty-three laboratories in fifteen countries. In the collaborative study described here, each of the three preparations was found to be suitable for use as a standard for insulin for bioassay and each was established by WHO in 1986 as an international standard. The 4th IS of Insulin bovine/porcine (code numbered 58/6) has been discontinued. Insulin preparations should now be calibrated in terms of International Units defined by the standard for the appropriate species: the International Standard for Insulin, Human, the International Standard for Insulin, Bovine, or the International Standard for Insulin, Porcine. |
| Databáze: | OpenAIRE |
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