| Autor: |
de Jager, Vincent D, de Visscher, Sebastiaan A H J, Schuuring, Ed, Doff, Jan J, van Kempen, Léon C |
| Přispěvatelé: |
Targeted Gynaecologic Oncology (TARGON), Damage and Repair in Cancer Development and Cancer Treatment (DARE) |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
GENES CHROMOSOMES & CANCER, 62(5), 297-300. Wiley |
| ISSN: |
1045-2257 |
| DOI: |
10.1002/gcc.23122 |
| Popis: |
Cribriform adenocarcinoma of salivary gland (CASG) is a rare, salivary gland tumor. In this report, we describe a case of CASG harboring a novel PPP2R2A::PRKD1 fusion. A 58-year-old female presented with an intraoral mass adjacent to the lower left third molar region. Morphological features at histological examination, immunohistochemical staining (p63+, p40-), and tumor location were indicative of CASG. However, due to the potential focal presence of a biphasic component within the tumor, RNA sequencing was performed to confirm the diagnosis. The subsequently found novel PPP2R2A::PRKD1 fusion adds to the rapidly evolving molecular landscape of salivary gland tumors. Additionally, we report that CASG may show some entrapment of pre-existent salivary gland ducts, which may be misinterpreted as tumor cells with myoepithelial differentiation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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