Development of a method for quantification of toluene diisocyanate and methylenediphenyl diisocyanate migration from polyurethane foam sample surface to artificial sweat by HPLC-UV-MS
| Autor: | Livain Breau, Sébastien Gagné, Mark Spence, Simon Aubin, Aleksandra Donchenko, Jacques Lesage |
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| Rok vydání: | 2019 |
| Předmět: |
Surface Properties
Movement Clinical Biochemistry Polyurethanes Air Pollutants Occupational 030226 pharmacology & pharmacy 01 natural sciences Biochemistry High-performance liquid chromatography Analytical Chemistry SWEAT 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tandem Mass Spectrometry Paint Humans Sweat Chromatography High Pressure Liquid Polyurethane Detection limit Chromatography Toluene diisocyanate Chemistry Hplc uv ms 010401 analytical chemistry Cell Biology General Medicine Environmental Exposure Isocyanate 0104 chemical sciences Test protocol Toluene 2 4-Diisocyanate Environmental Monitoring Isocyanates |
| Zdroj: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1142 |
| ISSN: | 1873-376X |
| Popis: | The US Environmental protection agency (EPA) has published guidance that includes test procedures for evaluating indoor exposure to chemicals from products. One of the test procedures represents the migration test for evaluating potential dermal exposure from home furniture. Such an evaluation involves the chemical measurement of the sweat which is currently unavailable in the literature. The objective of this project was to develop and validate an analytical method for quantification of migration of 4,4′-methylenediphenyl diisocyanate (MDI), 2,6-toluene diisocyanate (2,6-TDI) and 2,4-toluene diisocyanate (2,4-TDI) from a polyurethane (PU) flexible foam to artificial sweat that meets the recommendations of the EPA test protocol. Following the EPA protocol, six synthetic sweat solutions were prepared and used in evaluation of isocyanate recovery performance. The migration tests were conducted using five foam types that were chosen and supplied by PU foam manufacturers to represent the types most commonly found in commercial products, and with formulations anticipated to have the highest potential residual TDI or MDI. Migration tests were conducted using glass fiber filters (GFF) coated with 1-(2-methoxyphenyl)piperazine (1,2-MP) and analyzed using HPLC equipped with a UV detector for quantification and a MS detector to qualify peaks. The detection limits of the method were 0.002 µg/mL for 2,6-TDI, 0.011 µg/mL for 2,4-TDI, and 0.003 µg/mL for MDI. Quantification limits were 0.006 µg/mL, 0.037 µg/mL, and 0.010 µg/mL, respectively. The recovery tests on a Teflon surface for 5 of the 6 EPA-recommended synthetic sweat solutions indicate the recovery percentage was approximately 80% for diisocyanates. Recovery for the sixth sweat solution was low, approximately 30%. TDI and MDI migration was not observed when testing was conducted on foam samples. |
| Databáze: | OpenAIRE |
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