Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
| Autor: | Teruo Kuroda, Tsutomu Hatano, Yanmei Cui, Shoko Taniguchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Psoralea corylifolia
Ethyl acetate Pharmaceutical Science bakuflavanone Microbial Sensitivity Tests Acetates methicillin-resistant Staphylococcus aureus medicine.disease_cause Article Psoralea Analytical Chemistry Microbiology lcsh:QD241-441 Structure-Activity Relationship chemistry.chemical_compound Chalcones Phenols lcsh:Organic chemistry Drug Discovery medicine Physical and Theoretical Chemistry Bakuchiol bakuisoflavone Molecular Structure biology Traditional medicine Organic Chemistry biology.organism_classification Methicillin-resistant Staphylococcus aureus Anti-Bacterial Agents chemistry Chemistry (miscellaneous) Staphylococcus aureus Fruit Chromatography Gel Solvents Molecular Medicine |
| Zdroj: | Molecules, Vol 20, Iss 7, Pp 12500-12511 (2015) Molecules Volume 20 Issue 7 Pages 12500-12511 |
| ISSN: | 1420-3049 |
| Popis: | Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%–16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits. |
| Databáze: | OpenAIRE |
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