Angiotensin II attenuates the natriuresis of water immersion in humans
| Autor: | Peter Norsk, Harriet Dige-Petersen, Jørgen Warberg, Erik Frandsen, Anders Gabrielsen, Bettina Pump, Morten Schou, Niels Eske Bruun, Niels Juel Christensen, Peter Bie, Peter Skøtt |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology medicine.drug_class Natriuresis Kidney Cardiovascular Physiological Phenomena Excretion Electrolytes chemistry.chemical_compound Physiology (medical) Internal medicine Immersion Renin–angiotensin system medicine Humans Aldosterone Reabsorption Angiotensin II Water Blood Proteins Hormones Endocrinology chemistry Water immersion Mineralocorticoid |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 283:R187-R196 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.00536.2001 |
| Popis: | The hypothesis was tested that suppression of generation of ANG II is one of the mechanisms of the water immersion (WI)-induced natriuresis in humans. In one protocol, eight healthy young males were subjected to 3 h of 1) WI (WI + placebo), 2) WI combined with ANG II infusion of 0.5 ng · kg−1· min−1(WI + ANG II-low), and 3) a seated time control (Con). In another almost identical protocol, 7–10 healthy young males were investigated to delineate the tubular site(s) of action of ANG II by the lithium clearance method (CLi) and were on an additional fourth study day subjected to infusion of ANG II at a rate of 1.5 ng · kg−1· min−1(WI + ANG II-high). During WI + placebo, plasma concentration of ANG II decreased from 16 ± 2 to 8 ± 1 pg/ml ( P < 0.05) and renal sodium excretion increased from 104 ± 15 to 294 ± 27 μmol/min ( P < 0.05). During WI + ANG II-low, plasma ANG II was not suppressed by WI, and the natriuresis was blunted by 52 ± 13% ( P < 0.05). During WI + ANG II-low and WI + ANG II-high, an increase in CLiwas prevented that was otherwise observed during WI, and fractional distal reabsorption of sodium was facilitated. In conclusion, maintaining plasma concentration of ANG II unchanged at the level of control attenuates the natriuresis of WI considerably in humans. Therefore, suppression of generation of ANG II is an important mechanism of the natriuresis of WI in humans. Furthermore, infusion of ANG II during WI prevents an otherwise induced increase in CLiand facilitates the fractional distal reabsorption of sodium, probably via an effect on aldosterone release. |
| Databáze: | OpenAIRE |
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