Growth-promoting effect of environmental endocrine disruptors on human neuroblastoma SK-N-SH cells
| Autor: | Jiangbin Liu, Qiyou Yin, Shan Zheng, Jicui Zheng, Xianmin Xiao, Yong Yu |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pharmacology
endocrine system medicine.medical_specialty Bisphenol A urogenital system Chemistry Cell growth Health Toxicology and Mutagenesis Growth factor medicine.medical_treatment food and beverages Estrogen receptor General Medicine Toxicology medicine.disease chemistry.chemical_compound Endocrinology Cell culture Internal medicine Neuroblastoma medicine Cancer research Endocrine system Zearalenone hormones hormone substitutes and hormone antagonists |
| Zdroj: | Environmental toxicology and pharmacology. 24(2) |
| ISSN: | 1382-6689 |
| Popis: | Bisphenol A (BPA), a monomer component of polycarbonate plastics and epoxy resins, is widely used in many consumer products. Zearalenone (ZEA), a non-steroidal estrogenic mycotoxin, is present in high concentrations in dairy products and cereals. Numerous researches describe a possible correlation between environmental endocrine disruptors and human tumors, but only a few papers concerned solid tumors in childhood. We investigated the effects of BPA and ZEA on the proliferation in the human neuroblastoma SK-N-SH cell line. Cell counting kit-8 and flow cytometric analysis were used to determine whether BPA and ZEA promote cell proliferation. The results indicated that BPA and ZEA-mediated increase in cell proliferation is significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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