Pseudoscleroderma secondary to phytomenadione (vitamin K1) injections: Texier's disease
| Autor: | Steven Kossard, Vincent F. Munro, Bryan K Pang |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Aged
80 and over Male Vitamin Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Biopsy Needle Histology Vitamin K 1 Dermatology medicine.disease Connective tissue disease Scleroderma Scleroderma Localized chemistry.chemical_compound chemistry Biopsy Erythematous plaque medicine Etiology Humans Localized Scleroderma business Aged |
| Zdroj: | Australasian Journal of Dermatology. 37:44-47 |
| ISSN: | 1440-0960 0004-8380 |
| DOI: | 10.1111/j.1440-0960.1996.tb00994.x |
| Popis: | Cutaneous reactions to vitamin K1 (phytomenadione) are uncommon. They can present as acute eczematous reactions or late reactions that resemble localized scleroderma after vitamin K1 injections. A case is reported here of a patient who developed bilateral sclerodermoid plaques in a cowboy's holster pattern, which persisted for more than 10 years after subcutaneous vitamin K1 injections. Positive intradermal test with vitamin K1 that persisted as an erythematous indurated plaque at the test site for more than 5 months confirmed marked cutaneous hypersensitivity to vitamin K1 in this patient. Serial biopsies of the erythematous plaque at the test site showed transition from spongiotic eczematous features initially to inflammatory morphoea-like histology over a 5 month period. Possible pathogenic mechanisms for phytomenadione-induced pseudoscleroderma are discussed. |
| Databáze: | OpenAIRE |
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