Memory networks in tinnitus: a functional brain image study
| Autor: | Michele Vargas Garcia, Roberta Ribeiro de Almeida, Griselda J. Garrido, Ilza Rosa Batista, Andrea Parolin Jackowski, Marilia Alves dos Reis, Maura Regina Laureano, Adriana Neves de Andrade, Mario Luiz Vieira Castiglioni, Ektor Tsuneo Onishi, Rodrigo A. Bressan |
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| Přispěvatelé: | Universidade Federal de São Paulo (UNIFESP), Hosp Israelita Albert Einstein, Univ Western Australia |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Central Nervous System Circuit Models Pathology Anatomy and Physiology Sensory Physiology lcsh:Medicine Perfusion scanning Neural Homeostasis Otology Single-photon emission computed tomography Audiology Brain mapping Tinnitus Limbic system Learning and Memory Neural Pathways Neurobiology of Disease and Regeneration Medicine lcsh:Science Hearing Disorders Brain Mapping Multidisciplinary medicine.diagnostic_test Brain Sensory Systems medicine.anatomical_structure Cerebral blood flow Auditory System Cerebrovascular Circulation Female Sensory Perception medicine.symptom Research Article Nervous System Physiology Psychoacoustics Adult medicine.medical_specialty Neural Networks Neuroimaging Statistical parametric mapping Signaling Pathways Neurological System Imaging Three-Dimensional Developmental Neuroscience Memory Peripheral Nervous System otorhinolaryngologic diseases Humans Cerebral perfusion pressure Biology Demography Computational Neuroscience business.industry lcsh:R Neuroanatomy Pet Otorhinolaryngology Case-Control Studies Nervous System Components lcsh:Q Neural Circuit Formation Nerve Net Molecular Neuroscience business Neuroscience |
| Zdroj: | PLoS ONE, Vol 9, Iss 2, p e87839 (2014) PLoS ONE Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 1932-6203 |
| Popis: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Tinnitus is characterized by the perception of sound in the absence of an external auditory stimulus. the network connectivity of auditory and non-auditory brain structures associated with emotion, memory and attention are functionally altered in debilitating tinnitus. Current studies suggest that tinnitus results from neuroplastic changes in the frontal and limbic temporal regions. the objective of this study was to use Single-Photon Emission Computed Tomography (SPECT) to evaluate changes in the cerebral blood flow in tinnitus patients with normal hearing compared with healthy controls. Methods: Twenty tinnitus patients with normal hearing and 17 healthy controls, matched for sex, age and years of education, were subjected to Single Photon Emission Computed Tomography using the radiotracer ethylenedicysteine diethyl ester, labeled with Technetium 99 m (99 mTc-ECD SPECT). the severity of tinnitus was assessed using the Tinnitus Handicap Inventory (THI). the images were processed and analyzed using Statistical Parametric Mapping (SPM8). Results: A significant increase in cerebral perfusion in the left parahippocampal gyrus (pFWE |
| Databáze: | OpenAIRE |
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