Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release
| Autor: | Markus Neumeier, Gerd Schmitz, Charalampos Aslanidis, Gerhard Liebisch, Josef Wanninger, Ashraf Dada, Franziska Schober, Christa Buechler, S. Wurm, Johanna Weigert, Andreas Schäffler |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Gene isoform medicine.medical_specialty Biophysics Overweight Biochemistry Monocytes Body Mass Index Internal medicine medicine Humans Protein Isoforms Body Weights and Measures Secretion Obesity Interleukin 6 Molecular Biology Cells Cultured Aged biology Adiponectin Interleukin-6 Chemistry food and beverages nutritional and metabolic diseases Type 2 Diabetes Mellitus Cell Biology Middle Aged medicine.disease Molecular Weight Endocrinology Diabetes Mellitus Type 2 biology.protein medicine.symptom Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochemical and Biophysical Research Communications. 361:968-973 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2007.07.106 |
| Popis: | Adiponectin circulates as trimer (LMW), hexamer (MMW) and high molecular weight multimer (HMW) but the distribution and effects of these isoforms have not been studied in detail. Monocytes were isolated from normal weight and overweight controls and patients with type 2 diabetes mellitus (T2D) and monocytic release of IL-6 positively correlated with the body mass index (BMI). HMW-adiponectin further enhanced and LMW-adiponectin reduced IL-6 release in monocytes. Systemic total adiponectin, and the HMW isoform were not different in these groups but MMW-adiponectin was lower in T2D, and LMW-adiponectin was reduced in the obese and T2D. Circulating LMW-adiponectin negatively correlated to monocytic IL-6 release. Systemic IL-6 was higher in the obese control group and T2D, respectively, but did not correlate with monocytic IL-6 secretion. Therefore, the current study indicates that HMW-adiponectin exerts pro- and LMW-adiponectin antiinflammatory effects and reduced LMW-adiponectin in obesity may partly contribute to elevated monocytic IL-6 release. |
| Databáze: | OpenAIRE |
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