Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
| Autor: | April D. Pyle, Yifan Yu, Svenja Hinderer, Nancy Q. Liu, Frank A. Petrigliano, Mark Hurtig, Fabrizio Billi, Ruzanna Shkhyan, Liming Wang, J. Gage Crump, Jade Tassey, Aaron Kavanaugh, Jiankang Zhang, Yucheng Lin, Liangliang Li, Arijita Sarkar, Youngjoo Lee, Dawei Geng, Denis Evseenko, Kuo-Chang Tseng, Jay R. Lieberman, Gabriel B. Ferguson, Ben Van Handel, Jacob Bogdanov, Siyoung Lee, Katja Schenke-Layland |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Embryonic stem cells
business.industry Articular chondrocyte Biomedical Engineering Medicine (miscellaneous) Articular cartilage Cell Biology Osteoarthritis Articular surface Bioinformatics medicine.disease Embryonic stem cell Article Stem-cell research medicine.anatomical_structure Preclinical research Articular cartilage repair Medicine Fibrocartilage Regeneration business Cartilage repair Developmental Biology |
| Zdroj: | NPJ Regenerative Medicine npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2057-3995 |
| Popis: | Osteoarthritis (OA) impacts hundreds of millions of people worldwide, with those affected incurring significant physical and financial burdens. Injuries such as focal defects to the articular surface are a major contributing risk factor for the development of OA. Current cartilage repair strategies are moderately effective at reducing pain but often replace damaged tissue with biomechanically inferior fibrocartilage. Here we describe the development, transcriptomic ontogenetic characterization and quality assessment at the single cell level, as well as the scaled manufacturing of an allogeneic human pluripotent stem cell-derived articular chondrocyte formulation that exhibits long-term functional repair of porcine articular cartilage. These results define a new potential clinical paradigm for articular cartilage repair and mitigation of the associated risk of OA. |
| Databáze: | OpenAIRE |
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