Nanopore and nanoparticle formation with lipids, undergoing polymorphic phase transitions
| Autor: | Desislava Glushkova, Diana Cholakova, Nikolai D. Denkov, Slavka Tcholakova |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Phase transition
FOS: Physical sciences General Physics and Astronomy Nanoparticle 02 engineering and technology Condensed Matter - Soft Condensed Matter 010402 general chemistry 01 natural sciences Phase Transition Nanopores Surface-Active Agents Phase (matter) Physics - Chemical Physics Solid lipid nanoparticle General Materials Science Nanoscopic scale Chemical Physics (physics.chem-ph) Condensed Matter - Materials Science Chemistry General Engineering Materials Science (cond-mat.mtrl-sci) 021001 nanoscience & nanotechnology 0104 chemical sciences Nanopore Chemical engineering Soft Condensed Matter (cond-mat.soft) Nanoparticles Emulsions lipids (amino acids peptides and proteins) Wetting 0210 nano-technology Dispersion (chemistry) |
| Popis: | We describe several unexpected phenomena, caused by a solid-solid phase transition (gel-to-crystal) typical for all main classes of lipid substances - phospholipids, triglycerides, diglycerides, alkanes, etc. We discovered that this transition leads to spontaneous formation of a network of nanopores, spreading across the entire lipid structure. These nanopores are spontaneously impregnated (flooded) by water when appropriate surfactants are present, thus fracturing the lipid structure at a nano-scale. As a result, spontaneous disintegration of the lipid into nanoparticles or formation of double emulsions is observed, just by cooling and heating of an initial coarse lipid-in-water dispersion around the lipid melting temperature. The process of nanoparticle formation is effective even after incorporation of medical drugs of high load, up to 50 % in the lipid phase. The role of the main governing factors is clarified, the procedure is optimized, and the possibility for its scaling-up to industrially relevant amounts is demonstrated. |
| Databáze: | OpenAIRE |
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