Effects of Multiple Factorial Intervention on Ambulatory BP Profile and Renal Function in Hypertensive Type 2 Diabetic Patients with Overt Nephropathy – A Pilot Study
| Autor: | Tetsuya Fujikawa, Satoshi Umemura, Masato Ohsawa, Daisuke Suzuki, Hiromichi Wakui, Kouichi Tamura, Toru Dejima, Yasuko Okano, Shunsaku Mizushima, Tomoya Umezono, Sona Haku, Tomohiko Kanaoka, Nariaki Ogawa, Yusuke Konno, Hiroshi Mitsuhashi, Akinobu Maeda, Masao Toyoda, Mai Yanagi, Tadashi Yamakawa, Tatsumi Moriya, Keiji Tanaka, Satoshi Kondoh, Motoko Ozawa |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male Indoles Physiology Tetrazoles Blood Pressure Pilot Projects Comorbidity Kidney Fatty Acids Monounsaturated Diabetic nephropathy chemistry.chemical_compound Heart Rate Diabetic Nephropathies Prospective Studies Proteinuria Anticholesteremic Agents Valine General Medicine Blood Pressure Monitoring Ambulatory Middle Aged Lipids Circadian Rhythm Valsartan Hypertension Regression Analysis Female medicine.symptom Glomerular Filtration Rate medicine.drug medicine.medical_specialty Ambulatory blood pressure Urology Renal function Internal medicine Diabetes mellitus Internal Medicine medicine Albuminuria Humans Fluvastatin Antihypertensive Agents Creatinine business.industry medicine.disease Blood pressure Endocrinology Diabetes Mellitus Type 2 chemistry business |
| Zdroj: | Clinical and Experimental Hypertension. 33:255-263 |
| ISSN: | 1525-6006 1064-1963 |
| DOI: | 10.3109/10641963.2011.583971 |
| Popis: | Accumulating evidence has shown that diabetic patients are increasing in number, and renal and cardiovascular complications are the most common cause of death in diabetic patients. Thus, it would be of considerable value to identify the mechanisms involved in the progression of renal impairment and cardiovascular injury associated with diabetes. Recent evidence also indicated that multifactorial intervention is able to reduce the risk of cardiovascular disease and death among patients with diabetes and microalbuninuria. In this pilot study, we examined the effects of intensified multifactorial intervention, with tight glucose regulation and the use of valsartan and fluvastatin on ambulatory blood pressure (BP) profile, estimated glomerular filtration rate (eGFR), and urinary albumin to creatinine ratio (UACR), in 20 hypertensive patients (16 male and 4 female) with type 2 diabetes mellitus and overt nephropathy. After 12 months of intensified treatment, office BP, fasting plasma glucose (FPG), and low-density lipoprotein cholesterol (LDLC) were significantly decreased compared to baseline (systolic blood pressure (SBP), 130 ± 2 vs. 150 ± 1 mmHg; diastolic blood pressure (DBP), 76 ± 1 vs. 86 ± 1 mmHg; FPG, 117 ± 5 vs. 153 ± 7 mg/dl; LDLC, 116 ± 8 vs. 162 ± 5 mg/dl, P < 0.0001). Also, compared to the baseline values, the daytime and nighttime ambulatory BP and short-term BP variability were significantly decreased after 12 months. Furthermore, while eGFR was not altered (44.3 ± 5.1 vs. 44.3 ± 6.5 ml/min/1.73 m(2), not significant (NS)), UACR showed a significant reduction after 12 months of intensified treatment (1228 ± 355 vs. 2340 ± 381 mg/g-cr, P < 0.05). These results suggest that the intensified multifactorial intervention is able to improve ambulatory BP profile, preserve renal function, and reduce urinary albumin excretion in type 2 diabetic hypertensive patients with overt nephropathy. |
| Databáze: | OpenAIRE |
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