Novel approach to reduce postsurgical adhesions to a minimum: administration of losartan plus atorvastatin intraperitoneally
| Autor: | Ehsan Seyedjafari, Parisa Sanaei-rad, Babak Dinarvand, Shirin Farhadian, Masoud Soleimani, Arash Jalali, Abbas Shafiee, Peyman Dinarvand |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Mrna expression Atorvastatin Sodium hyaluronate Tissue Adhesions Pharmacology Losartan Transforming Growth Factor beta1 chemistry.chemical_compound Angiotensin Receptor Antagonists Mice Postoperative Complications Scaling methods Internal medicine Plasminogen Activator Inhibitor 1 medicine Animals Pyrroles RNA Messenger business.industry Pelvic pain Serum concentration Endocrinology chemistry Nmri mice Heptanoic Acids Tissue Plasminogen Activator Surgery medicine.symptom Hydroxymethylglutaryl-CoA Reductase Inhibitors business Injections Intraperitoneal medicine.drug |
| Zdroj: | The Journal of surgical research. 181(1) |
| ISSN: | 1095-8673 |
| Popis: | Background: Intraperitoneal adhesions are the most important cause of intestinal obstruction, pelvic pain, and female infertility.Materials and methods: Losartan (1, 5, and 10 mg/kg), atorvastatin (1, 20, and 30 mg/kg), losartan (10 mg/kg) plus atorvastatin (20 mg/kg), and sodium hyaluronate/carboxymethylcellulose (HA/CMC) were administered intraperitoneally in 90 male NMRI mice. After 7 d, the grade of adhesions was scored by two scaling methods and the concentrations of TGF-beta 1, tPA, and PAI-1 were also evaluated.Results: Simultaneous intraperitoneal administration of losartan and atorvastatin led to a much higher reduction of adhesions compared with that in the HA/CMC group (P < 0.05). When losartan plus atorvastatin was administered, significant changes in the serum concentration and mRNA expression, including the increase of tPA and the decrease of TGF-beta 1 and PAI-1, were observed compared with those in other groups.Conclusions: Our findings suggest that the simultaneous application of losartan and atorvastatin leads to an enhanced reduction in adhesion bands more than that of HA/CMC treatment, compared with the control group, possibly through balancing the expression of TGF-beta, tPA, and PAI-1. (C) 2013 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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