The role of the B lymphocytes in endometriosis: A systematic review

Autor: Mauricio Simões Abrão, Frédéric Batteux, Charles Chapron, L. G. C Riccio, Edmund Chada Baracat
Přispěvatelé: Riccio, Luiza, Institut National de la Santé et de la Recherche Médicale ( INSERM )
Rok vydání: 2017
Předmět:
0301 basic medicine
[SDV.IMM] Life Sciences [q-bio]/Immunology
Immunology
Endometriosis
B-Lymphocyte Subsets
Pathogenesis
Disease
Antibodies
03 medical and health sciences
Endometrium
0302 clinical medicine
Immune system
[ SDV.IMM ] Life Sciences [q-bio]/Immunology
Immunology and Allergy
Medicine
Animals
Humans
[ SDV.MHEP.GEO ] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Autoantibodies
Autoimmune disease
B cells
B-Lymphocytes
030219 obstetrics & reproductive medicine
biology
business.industry
Autoantibody
Obstetrics and Gynecology
medicine.disease
Pathophysiology
[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
030104 developmental biology
Reproductive Medicine
biology.protein
Female
Antibody
Inflammation Mediators
business
Biomarkers
B lymphocytes
Zdroj: Journal of Reproductive Immunology
Journal of Reproductive Immunology, Elsevier, 2017, 123, pp.29-34. 〈10.1016/j.jri.2017.09.001〉
ISSN: 1872-7603
0165-0378
DOI: 10.1016/j.jri.2017.09.001〉
Popis: International audience; The physiopathology of endometriosis is not completely understood and its progression is associated with a local and systemic inflammatory reaction. It is important to clarify the potential role of the immune system to better understand its implication in the pathogenesis of endometriosis, which includes the study of the role of B cells and antibodies. The aim of this study was to review the literature about the role of B lymphocytes in endometriosis. A search for "endometriosis", "B cells" and "B lymphocytes" in databases resulted in 140 citations; after applying inclusion and exclusion criteria, a total of 22 studies were assessed. The analyzed samples in the studies varied and different markers and techniques were used by the authors to evaluate the direct or indirect role of B lymphocytes in endometriosis. Most studies demonstrated increased number and/or activation of B cells while seven studies found no difference and two studies showed decreased number of B cells. Increased B lymphocytes and excessive production of autoantibodies in endometriosis have been described in the literature, but their role in the development of the disease is not well understood. Moreover, the association of these factors with clinical symptoms, location and severity of the disease has not been investigated. Further studies are necessary to clarify the role of B cells in the development of endometriosis and propose new therapeutic strategies such as the use of drugs that target these cells.
Databáze: OpenAIRE
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