Drug Insight: cancer cell immortality—telomerase as a target for novel cancer gene therapies
| Autor: | T.R. Jeffry Evans, Maryon Hardie, W. Nicol Keith, Alan Bilsland |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Drug
Telomerase Genetic enhancement media_common.quotation_subject Bioinformatics Neoplasms Biomarkers Tumor Humans Medicine Prodrugs Enzyme Inhibitors Gene Cellular Senescence media_common Cell Death business.industry Cancer Genetic Therapy General Medicine Telomere medicine.disease Phenotype Cell Transformation Neoplastic Oncology Cancer cell RNA Cancer gene business |
| Zdroj: | Nature Clinical Practice Oncology. 1:88-96 |
| ISSN: | 1743-4262 1743-4254 |
| DOI: | 10.1038/ncponc0044 |
| Popis: | Untangling the complex pathways underlying the major cancer phenotypes remains a significant challenge, but deregulated expression of a single multi-component enzyme, telomerase, is implicated as a causative factor for immortalization in the vast majority of human tumors. This review highlights the potential of telomerase as a target for novel cancer gene therapies. Rapid advances in our understanding of the molecular basis of cancer development and progression over the past three decades have led to the design of new potential cancer therapies. High throughput target validation and expression studies are expected to yield a powerful arsenal of new cancer treatments, but untangling the complex pathways underlying the major cancer phenotypes remains a significant challenge. A considerable body of evidence in recent years implicates deregulated expression of a single multi-component enzyme, telomerase, as a causative factor at the heart of immortalization in the vast majority of human tumors. This review highlights the potential of telomerase as a target for novel cancer therapies. The potential of exploiting the selectivity of the telomerase family of genes within cancer cells to develop gene therapy strategies is discussed, and the progress towards translating these novel therapeutics from the laboratory to the clinic is reviewed. |
| Databáze: | OpenAIRE |
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