Normative Volumetric Data of the Developing Hippocampus in Children Based on Magnetic Resonance Imaging
| Autor: | Joseph Egger, Roland Scheck, Klaus Hahn, Christian Vollmar, Thomas Pfluger, Serge Weis, Sabine Weil, D. Heiss |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Adolescent Coefficient of variation Hippocampus Hippocampal formation Functional Laterality Random Allocation Epilepsy Sex Factors Reference Values medicine Humans Child Retrospective Studies Hippocampal sclerosis medicine.diagnostic_test Age Factors Brain Infant Magnetic resonance imaging Anatomy medicine.disease Magnetic Resonance Imaging Sagittal plane Accelerated Growth medicine.anatomical_structure Neurology Child Preschool Female Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1528-1167 0013-9580 |
| DOI: | 10.1111/j.1528-1157.1999.tb00735.x |
| Popis: | Summary: Purpose: To acquire normative data of the hippocampus and its postnatal growth in 50 children (age, 1 month to 15 years) without epilepsy. Methods: Morphometry of the hippocampus was carried out by using a spoiled FLASH 3D sequence (sagittal orientation), whereas the volume of the brain was assessed with a T2-weighted spin-echo sequence (transverse orientation). The volume of the hippocampus and the brain was determined by following Cavalieri's principle. Growth curves of the brain and hippocampus were fitted to a nonlinear Boltzmann sigmoidal equation. Results: Intra-/interobserver coefficient of variation was 2.0/4.9% for hippocampal volume measurements and 2.0/2.1% for brain volumetry. A significant difference in volume was noted between the right and left hippocampus (p < 0.001), with the right side being larger on average by 0.10 cc. Correlation coefficients of growth curves ranged between 0.71 and 0.94. Growth curves demonstrated a faster development of the hippocampus in girls. A steeper slope of hippocampal growth as compared with brain growth was found in girls, whereas in boys, the slope of brain growth was steeper. Conclusions: Our findings will be of help in evaluating vulnerable phases of the hippocampal formation with accelerated growth, thereby leading to a better understanding of the development of hippocampal sclerosis in early childhood. |
| Databáze: | OpenAIRE |
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