Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring
| Autor: | Nail Burnashev, Vera Tsintsadze, Geneviève Chazal, Ilgam Khalilov, Yehezkel Ben-Ari, Roman Tyzio, Natalia Lozovaya, Romain Nardou, Eric Lemonnier, Corinne Brouchoud, Timur Tsintsadze, Diana C. Ferrari, Sanaz Eftekhari, Amene Shahrokhi |
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| Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Archéologie des Amériques (ArchAm), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Offspring [SDV.BC]Life Sciences [q-bio]/Cellular Biology Hippocampal formation Biology Oxytocin Neuroprotection Fragile X Mental Retardation Protein Mice Glutamatergic Chlorides Pregnancy Internal medicine medicine Animals Autistic Disorder Maternal-Fetal Exchange Bumetanide gamma-Aminobutyric Acid ComputingMilieux_MISCELLANEOUS Multidisciplinary Behavior Animal Valproic Acid Parturition medicine.disease Rats Disease Models Animal Endocrinology Cytoprotection Excitatory postsynaptic potential Autism Female [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie medicine.drug |
| Zdroj: | Science Science, American Association for the Advancement of Science, 2014, 343, pp.675--679. ⟨10.1126/science.1247190⟩ Science, 2014, 343, pp.675--679. ⟨10.1126/science.1247190⟩ |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | The Switch That Doesn't In mammals, a class of neurons in the brain normally switches from excitatory to inhibitory functions at birth. Tyzio et al. (p. 675 ; see the Perspective by Zimmerman and Connors ) studied how these neurons function in rat and mouse models of autism. The results show that oxytocin normally accelerates the switch in function, but in these two animal models, the switch fails. The dysfunction could be replicated in normal animals using an oxytocin receptor antagonist. |
| Databáze: | OpenAIRE |
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