Prevalence and clinical course of viral upper respiratory tract infections in immunocompromised pediatric patients with malignancies or after hematopoietic stem cell transplantation
| Autor: | Karin Hammer, Andishe Attarbaschi, Thomas Lion, Andreas Vécsei, Tamas Fazekas, Ulrike Pötschger, Margit Rauch, Philipp Eickhoff, Maria Verdianz, Christina Peters, Michael Dworzak |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Prospective data Hematopoietic stem cell transplantation Immunocompromised Host Risk Factors Internal medicine Neoplasms medicine Prevalence Humans Prospective Studies Respiratory system Intensive care medicine Child Respiratory Tract Infections Respiratory tract infections business.industry Incidence (epidemiology) Clinical course Hematopoietic Stem Cell Transplantation Infant Hematology Prognosis Transplantation Survival Rate surgical procedures operative Blood Disorder Oncology Virus Diseases Austria Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Viruses Female business |
| Zdroj: | Journal of pediatric hematology/oncology. 34(6) |
| ISSN: | 1536-3678 |
| Popis: | Respiratory tract infections (RTI) in immunosuppressed pediatric patients with malignancies or after hematopoietic stem cell transplantation (HSCT) are associated with significant morbidity and mortality. Prospective data on the incidence and clinical role of infections by respiratory viruses in this population have been lacking.In this prospective study, 191 children between 0 and 18 years of age were investigated by real-time polymerase chain reaction for the presence of 8 common respiratory virus types in transnasal aspirations. The study included 110 children with leukemia, lymphoma, or solid tumors (subgroup 1); 31 children after HSCT (subgroup 2); and 50 immunocompetent control patients.In comparison with the control group, immunocompromised children showed a significantly higher incidence of positive virus tests (subgroup 1: 53%; subgroup 2: 81%; controls: 24%; P0.0001), and more frequently experienced ensuing viral infections in the lower respiratory tract (subgroup 1: 74%; subgroup 2: 88%; controls: 25%; P0.0001). Sixteen percent of these children had coinfections by 2 or more viruses and revealed more severe respiratory illness.The present epidemiologic study on viral upper RTI in immunocompromised children revealed a high virus-associated morbidity which was particularly prominent in HSCT recipients. In these children, detection of viral coinfections was identified as a risk factor for a severe course of lower RTI. |
| Databáze: | OpenAIRE |
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