Evaluating tumors in transcatheter arterial chemoembolization (TACE) using dual-phase cone-beam CT

Autor: Jean Francois H. Geschwind, Romaric Loffroy, MingDe Lin, Järl Blijd, Katsuyuki Taguchi, Angelique Balguid, Niels Noordhoek, Alessandro Radaelli
Rok vydání: 2010
Předmět:
Zdroj: Minimally Invasive Therapy & Allied Technologies. 20:276-281
ISSN: 1365-2931
1364-5706
DOI: 10.3109/13645706.2010.536243
Popis: C-arm cone-beam computed tomography (CBCT) can be used to visualize tumor-feeding vessels and parenchymal staining during transcatheter arterial chemoembolization (TACE). To capture these two phases, all current commercially available CBCT systems necessitate two separate contrast-enhanced scans. In this feasibility study, we report initial results of novel software that enhanced our current CBCT system to capture these two phases using only one contrast injection. Novelty of this work is the addition of software that enabled the acquisition of two sequential, back-to-back CBCT scans (dual-phase CBCT, DPCBCT) so both tumor feeding vessels and parenchyma are captured using only one contrast injection. To illustrate our initial experience, DPCBCT was used for TACE treatments involving lipiodol, drug-eluting beads, and Yttrium-90 radioembolizing microspheres. For each case, the DPCBCT images were compared to pre-intervention contrast-enhanced MR/CT. DPCBCT is feasible for TACE treatments and the preliminary results show positive correlation with pre-intervention conventional CT and MR. In addition, the degree of embolization can be monitored. DPCBCT is a promising technology that provides comprehensive visualization of tumor-feeding vessels and parenchymal staining using a single injection of contrast. DPCBCT could potentially be used during TACE to verify catheter position and monitor the embolization effect.
Databáze: OpenAIRE