Solitary uterine metastasis of invasive lobular carcinoma after adjuvant endocrine therapy: a case report
| Autor: | Atsushi Hayasaka, Nobuko Ishigaki, Saori Igeta, Takashi Shima, Kosuke Yoshinaga, Hideki Iwahashi, Hiroyoshi Suzuki, Kozo Akagi, Hiromitsu Makino, Takako Kudo, Masafumi Toyoshima, Junko Sakurada, Rui Matsuura |
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| Jazyk: | angličtina |
| Předmět: |
Oncology
medicine.medical_specialty Antineoplastic Agents Hormonal Isolated uterine metastasis Breast Neoplasms Case Report Anastrozole Metastasis Breast cancer Internal medicine Nitriles Biomarkers Tumor medicine Carcinoma Humans skin and connective tissue diseases Uterine Neoplasm Glycoproteins Medicine(all) Leiomyoma business.industry Membrane Transport Proteins General Medicine Middle Aged Triazoles Invasive lobular carcinoma medicine.disease Combined Modality Therapy Immunohistochemistry Metastatic breast cancer Carcinoma Lobular Uterine Neoplasms Hormonal therapy Female Radiology Carrier Proteins business |
| Zdroj: | Journal of Medical Case Reports |
| ISSN: | 1752-1947 |
| DOI: | 10.1186/s13256-014-0511-6 |
| Popis: | Introduction Solitary uterine metastases from extragenital cancers are very rare. Breast cancer is the most frequent primary site of metastasis to the uterine corpus, with invasive lobular carcinoma more likely to spread to gynecologic organs than invasive ductal carcinoma. Case presentation A 62-year-old postmenopausal Japanese woman was diagnosed with uterine leiomyomata more than 20 years ago and had been managed conservatively until menopause. Seven years prior to her presentation, she was diagnosed with breast cancer and underwent a partial resection of her right breast for stage IIA invasive lobular carcinoma. She underwent adjuvant chemotherapy, radiotherapy, and five years of anastrozole hormonal therapy. She presented with a growing uterine mass. Her tumor marker levels were markedly increased over the course of her follow-up, but a systemic examination revealed only a solitary uterine tumor. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. A histopathological examination, including detailed immunohistochemistry, confirmed metastatic invasive lobular carcinoma, infiltrating both her uterine myometrium and fibroid tissue. Conclusion We report a very rare metastatic pattern of invasive lobular carcinoma and demonstrate that gross cystic disease fluid protein-15 and mammaglobin are useful in the diagnosis of metastatic breast cancer. |
| Databáze: | OpenAIRE |
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