Assessment of expression of oxytocin-related lncRNAs in schizophrenia

Autor: Reyhane, Eghtedarian, Mohammadarian, Akbari, Elham, Badrlou, Bashdar, Mahmud Hussen, Solat, Eslami, Mehdi, Akhavan-Bahabadi, Mohammad, Taheri, Soudeh, Ghafouri-Fard, Seyedeh Morvarid, Neishabouri
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Pharmacology. 932:175205
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2022.175205
Popis: Schizophrenia is a neuropsychiatric disorder characterized by a variety of clinical manifestations. This disorder has a complex inheritance. Oxytocinegic system has been shown to be implicated in the pathophysiology of schizophrenia. This system can alter social cognition through direct interaction with dopaminergic signaling, facilitating brain-stimulation reward, reduction of defense mechanism and stress reactivity, and modulation of social information processing through enhancing the greatness of social incentives. Long non-coding RNAs (lncRNAs) can affect activity of oxytocinegic system, thus contributing in the etiology of this disorder.We designed the current study to appraise dysregulation of nine oxytocin-associated mRNAs and lncRNAs in the venous blood of patients with schizophrenia.Expression of FOS was up-regulated in total patients compared with total control group (Expression ratio (95% CI)= 13.64 (5.46-34.05), adjusted P value0.0001) and in female patients compared with female control group (Expression ratio (95% CI)=32.13 (5.81-176), adjusted P value0.0001). Such pattern was also seen for Lnc-FOXF1 (Expression ratio (95% CI)= 6.41 (2.84-14.3), adjusted P value0.0001 and Expression ratio (95% CI)= 14.41 (3.2-64.44), adjusted P value0.0001, respectively). ITPR1 was down-regulated in total patients compared with total controls (Expression ratio (95% CI)= 0.22 (0.076-0.67), adjusted P value=0.0079). ROC curve analyses demonstrated that FOS had the best AUC value among other genes in differentiation between patients and controls (AUC=0.78).The above-mentioned results imply dysregulation of oxytocin-related genes in the circulatory blood of patients with schizophrenia.
Databáze: OpenAIRE
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