A maternal high-fat diet during pregnancy and lactation, in addition to a postnatal high-fat diet, leads to metabolic syndrome with spatial learning and memory deficits: beneficial effects of resveratrol
| Autor: | Mao-Meng Tiao, Shih-Wen Li, Hong-Ren Yu, Ching-Chou Tsai, I-Chun Lin, Jiunn-Ming Sheen, Yu-Ju Lin, Kow-Aung Chang, Li-Tung Huang, You-Lin Tain |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
hippocampus Offspring Morris water navigation task Physiology resveratrol Resveratrol Impaired glucose tolerance 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Lactation medicine Pregnancy business.industry maternal high-fat diet/obesity medicine.disease spatial 030104 developmental biology medicine.anatomical_structure Oncology chemistry Metabolic syndrome postnatal high-fat diet business 030217 neurology & neurosurgery Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.22960 |
| Popis: | // Shih-Wen Li 1, 2 , Hong-Ren Yu 1 , Jiunn-Ming Sheen 1 , Mao-Meng Tiao 1 , You-Lin Tain 1 , I-Chun Lin 1 , Yu-Ju Lin 3 , Kow-Aung Chang 4 , Ching-Chou Tsai 5 and Li-Tung Huang 1, 6 1 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 2 Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan 3 Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan 4 Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan 5 Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan 6 Department of Traditional Medicine, Chang Gung University, Linkow, Taiwan Correspondence to: Li-Tung Huang, email: litung.huang@gmail.com Keywords: maternal high-fat diet/obesity; spatial; resveratrol; postnatal high-fat diet; hippocampus Received: August 16, 2017 Accepted: November 17, 2017 Published: December 06, 2017 ABSTRACT We tested the hypothesis that high-fat diet consumption during pregnancy, lactation, and/or post weaning, altered the expression of molecular mediators involved in hippocampal synaptic efficacy and impaired spatial learning and memory in adulthood. The beneficial effect of resveratrol was assessed. Dams were fed a rat chow diet or a high-fat diet before mating, during pregnancy, and throughout lactation. Offspring were weaned onto either a rat chow or a high-fat diet. Four experimental groups were generated, namely CC, HC, CH, and HH (maternal chow diet or high-fat diet; postnatal chow diet or high-fat diet). A fifth group fed with HH plus resveratrol (HHR) was generated. Morris water maze test was used to evaluate spatial learning and memory. Blood pressure and IPGTT was measured to assess insulin resistance. Dorsal hippocampal expression of certain biochemical molecules, including sirtuin 1, ERK, PPARγ, adiponectin, and BDNF were measured. Rats in HH group showed impaired spatial memory, which was partly restored by the administration of resveratrol. Rats in HH group also showed impaired glucose tolerance and increased blood pressure, all of which was rescued by resveratrol administration. Additionally, SIRT1, phospho-ERK1/2, and phospho-PPARγ, adiponectin and BDNF were all dysregulated in rats placed in HH group; administration of resveratrol restored the expression and regulation of these molecules. Overall, our results suggest that maternal high-fat diet during pregnancy and/or lactation sensitizes the offspring to the adverse effects of a subsequent high-fat diet on hippocampal function; however, administration of resveratrol is demonstrated to be beneficial in rescuing these effects. |
| Databáze: | OpenAIRE |
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