Plasmatic Levels of Neuropeptides, Including Oxytocin, in Children with Autism Spectrum Disorder, Correlate with the Disorder Severity
| Autor: | Monica Neagu, C.G. Anghel, Bădescu Sv, O. I. Geicu, Iuliana Dobrescu, I. Mocanu, Florina Rad, Anca Maria Panaitescu, Ana-Maria Zagrean, Carolina Constantin, Leon Zagrean, L. Kobylinska, Ilinca Mihailescu, G. Gabreanu, C. Nedelcu |
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| Rok vydání: | 2019 |
| Předmět: |
endocrine system
medicine.medical_specialty Endocrinology Diabetes and Metabolism Neuropeptide Context (language use) Autism Diagnostic Observation Schedule 03 medical and health sciences Orexin-A 0302 clinical medicine Endocrinology Internal medicine mental disorders medicine General Endocrinology Endocrine and Autonomic Systems business.industry medicine.disease 030227 psychiatry Oxytocin Autism spectrum disorder Autism business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Neurotypical medicine.drug |
| Zdroj: | Acta Endocrinologica (Bucharest). 15:16-24 |
| ISSN: | 1843-066X 1841-0987 |
| Popis: | Context Oxytocin has been investigated as a potential medication for psychiatric disorders. Objective and design This study prospectively investigates correlations between oxytocin and other neuropeptides plasma levels in patients with autism spectrum disorders (ASD) according to severity and treatment, as compared to controls. Subjects and methods Thirty-one children (6 neurotypical as control) participated in this study. The patients were classified into mildly and severely-affected, according to Autism Diagnostic Observation Schedule (ADOS) scores. Oxytocin, orexin A and B, α-MSH, β-endorphins, neurotensin and substance P were investigated using a quantitative multiplex assay or a competitive-ELISA method. Results Plasma oxytocin levels differed between the groups (F (2, 24) =6.48, p=0.006, η2=0.35, observed power=86%): patients with the mild ASD had higher values of plasma oxytocin than those with the severe form (average difference=74.56±20.74pg/mL, p=0.004). Conclusions These results show a negative correlation between plasma levels of oxytocin and the severity of ASD and support the involvement of oxytocinergic mechanisms in ASD. |
| Databáze: | OpenAIRE |
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