Biochemical effect evaluation of perfluorooctane sulfonic acid-contaminated wood mice (**Apodemus sylvaticus**)
Autor: | Wim De Coen, Jan Scheirs, Kristin Van de Vijver, Eddy L. Esmans, Ronny Blust, Walter Van Dongen, Philippe Tony Hoff |
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Jazyk: | angličtina |
Rok vydání: | 2004 |
Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis Lipid peroxidation chemistry.chemical_compound Sex Factors Internal medicine medicine Animals Tissue Distribution Muridae Fluorocarbons biology Triglyceride Cholesterol Fatty Acids Public Health Environmental and Occupational Health Alanine Transaminase biology.organism_classification Mitochondria Endocrinology chemistry Alanine transaminase Biochemistry Alkanesulfonic Acids Liver Catalase Bioaccumulation biology.protein Microsome Environmental Pollutants Female Lipid Peroxidation Research Article |
Zdroj: | Environmental health perspectives Environmental Health Perspectives |
ISSN: | 0091-6765 |
Popis: | Wood mice (Apodemus sylvaticus) were captured at Blokkersdijk, a nature reserve in the immediate vicinity of a fluorochemical plant in Antwerp, Belgium, and at Galgenweel, 3 kilometers farther away. The liver perfluorooctane sulfonic acid (PFOS) concentrations in the Blokkersdijk mice were extremely high (0.47-178.55 micro g/g wet weight). Perfluorononanoic, perfluorodecanoic, perfluoroundecanoic, and perfluorododecanoic acids were found sporadically in the liver tissue of the Blokkersdijk mice. The liver PFOS concentrations at Galgenweel were significantly lower than those at Blokkersdijk (0.14-1.11 micro g/g wet weight). Further results suggest sex independence of the liver PFOS levels, increased levels of PFOS bioaccumulation in older mice, and maternal PFOS transfer to the young. Several liver end points were significantly elevated in the Blokkersdijk mice: liver weight, relative liver weight, peroxisomal beta-oxidation activity, microsomal lipid peroxidation level, and mitochondrial fraction protein content. For the mitochondrial fraction catalase activity, no significant difference between locations was found. The liver weight, relative liver weight, and liver microsomal lipid peroxidation level increased significantly with the liver PFOS concentration. No indications for PFOS-mediated effects on the serum triglyceride, cholesterol, or potassium levels were obtained. The liver PFOS concentration was negatively related to the serum alanine aminotransferase activity. |
Databáze: | OpenAIRE |
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