Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats
| Autor: | Robert Dantzer, Fred J.H. Tilders, M. J. P. Lenczowski, Joachim Roth, G. S. Rees, R. M. Bluthe, A.-M. Van Dam, Nancy J. Rothwell, David Rushforth, Giamal N. Luheshi |
|---|---|
| Přispěvatelé: | ProdInra, Migration, Anatomy and neurosciences, AMS - Ageing & Vitality, AMS - Tissue Function & Regeneration, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Neuroinfection & -inflammation, Clinical pharmacology and pharmacy, Unité mixte de recherche neurobiologie intégrative, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System medicine.medical_specialty Fever Physiology [SDV]Life Sciences [q-bio] medicine.medical_treatment Central nervous system Pituitary-Adrenal System Adrenocorticotropic hormone Motor Activity Body Temperature 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adrenocorticotropic Hormone Corticosterone Physiology (medical) Internal medicine medicine Animals Humans Potency Rats Wistar Social Behavior Interleukin 6 Sickness behavior ComputingMilieux_MISCELLANEOUS Injections Intraventricular 030304 developmental biology 0303 health sciences Behavior Animal biology Interleukin-6 Interleukin Recombinant Proteins Rats [SDV] Life Sciences [q-bio] Endocrinology medicine.anatomical_structure Cytokine chemistry biology.protein RAT Psychology 030217 neurology & neurosurgery |
| Zdroj: | Lenczowski, M J P, Bluthé, R M, Roth, J, Rees, G S, Rushforth, D A, Van Dam, A M, Tilders, F J H, Dantzer, R, Rothwell, N J & Luheshi, G N 1999, ' Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats ', American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 276, no. 3 45-3, pp. R652-R658 . https://doi.org/10.1152/ajpregu.1999.276.3.r652 American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 276(3 45-3), R652-R658. American Physiological Society AJP-Regulatory, Integrative and Comparative Physiology AJP-Regulatory, Integrative and Comparative Physiology, American Physiological Society, 1999, 276, pp.R652-R658 Scopus-Elsevier |
| ISSN: | 0363-6119 1522-1490 |
| DOI: | 10.1152/ajpregu.1999.276.3.r652 |
| Popis: | Interleukin (IL)-6 has been proposed to mediate several sickness responses, including brain-mediated neuroendocrine, temperature, and behavioral changes. However, the exact mechanisms and sites of action of IL-6 are still poorly understood. In the present study, we describe the effects of central administration of species-homologous recombinant rat IL-6 (rrIL-6) on the induction of hypothalamic-pituitary-adrenal (HPA) activity, fever, social investigatory behavior, and immobility. After intracerebroventricular administration of rrIL-6 (50 or 100 ng/rat), rats demonstrated HPA and febrile responses. In contrast, rrIL-6 alone did not induce changes in social investigatory and locomotor behavior at doses of up to 400 ng/rat. Coadministration of rrIL-6 (100 ng/rat) and rrIL-1β (40 ng/rat), which alone did not affect the behavioral responses, reduced social investigatory behavior and increased the duration of immobility. Compared with rhIL-6, intracerebroventricular administration of rrIL-6 (100 ng/rat) induced higher HPA responses and early-phase febrile responses. This is consistent with a higher potency of rrIL-6, compared with rhIL-6, in the murine B9 bioassay. We conclude that species-homologous rrIL-6 alone can act in the brain to induce HPA and febrile responses, whereas it only reduces social investigatory behavior and locomotor activity in the presence of IL-1β. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|