Tolerability of Topical Treatments for Atopic Dermatitis
Autor: | Brian Berman, Zoe Diana Draelos, Melissa Olivadoti, Anna M. Tallman, William C. Ports, Sheryl Baldwin, Steven R. Feldman, Debra Sierka, Michael A. Zielinski |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
medicine.drug_class Review Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Calcineurin inhibitor lcsh:Dermatology Medicine Corticosteroid Medical prescription Adverse effect Atopic dermatitis business.industry Crisaborole lcsh:RL1-803 Tolerability medicine.disease Application site reaction Clinical trial Calcineurin 030220 oncology & carcinogenesis Topical therapy business Application site pain |
Zdroj: | Dermatology and Therapy, Vol 9, Iss 1, Pp 71-102 (2019) Dermatology and Therapy |
ISSN: | 2190-9172 2193-8210 |
DOI: | 10.1007/s13555-019-0280-7 |
Popis: | Atopic dermatitis (AD) is a common inflammatory skin disease that is accompanied by increased sensitivity to itch-provoking and pain-provoking stimuli. Patients with AD experience skin pain before initiation of therapy and have also reported painful application site reactions in clinical trials of emollients and prescription topical therapies, including topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and a topical phosphodiesterase 4 (PDE4) inhibitor. To compare the sensory tolerability of prescription topical therapies for AD, a comprehensive literature search and analysis of published clinical trials was conducted. Sensory tolerability issues such as application site pain, burning, stinging, and pruritus were often among the most common adverse events or treatment-related adverse events in clinical trials for prescription topical therapies. Tolerability issues occurred at highest rates in trials of TCIs, followed by trials of the PDE4 inhibitor crisaborole and TCSs, although direct comparisons are not possible because of differences in study design. Tolerability issues in these clinical trials were generally mild to moderate and transient. This article also reviews published strategies for managing sensory tolerability issues in AD patients during treatment with topical therapies. Funding: Pfizer Inc., New York, NY. |
Databáze: | OpenAIRE |
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