Neuroprotective Effects of Garlic A Review
| Autor: | Biju Rs, Mathew Bc |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Antioxidant
anti-atherogenic medicine.medical_treatment lcsh:Medicine Review Article Pharmacology medicine.disease_cause Neuroprotection chemistry.chemical_compound garlic medicine Dementia anti-apoptotic Vascular dementia chemistry.chemical_classification Reactive oxygen species Cholesterol business.industry anti-oxidant lcsh:R food and beverages neuroprotective General Medicine medicine.disease chemistry Toxicity business Oxidative stress |
| Zdroj: | Libyan Journal of Medicine; Vol 3, No 1 (2008); 23-33 Libyan Journal of Medicine, Vol 3, Iss 1, p AOP:071118 (2008) The Libyan Journal of Medicine |
| ISSN: | 1993-2820 1819-6357 |
| Popis: | Garlic has been investigated extensively for health benefits, resulting in more than one thousand publications over the last decade alone. It is considered one of the best disease preventive foods, based on its potent and varied effects. Midlife risk factors for cardiovascular diseases, such as high serum total cholesterol, raised LDL, increased LDL oxidation, increased platelet aggregation, impaired fibrinolysis, hypertension and homocystinemia are important risk factors for dementia in later years. These risk factors play a major role in the genesis of atherosclerosis of vital arteries causing both cardiovascular and cerebrovascular disease. Garlic is best known for its lipid lowering and anti-atherogenic effects. Possible mechanisms of action include inhibition of the hepatic activities of lipogenic and cholesterogenic enzymes that are thought to be the genesis for dyslipidemias, increased excretion of cholesterol and suppression of LDL-oxidation. Oxidative stress caused by increased accumulation of reactive oxygen species (ROS) in cells has been implicated in the pathophysiology of several neurodegenerative diseases including Alzheimer's disease (AD). Several studies have demonstrated the antioxidant properties of garlic and its different preparations including Aged Garlic Extract (AGE). AGE and S-allyl-cysteines (SAC), a bioactive and bioavailable component in garlic preparations have been shown in a number of in vitro studies to protect neuronal cells against beta-amyloid (A ) toxicity and apoptosis. Thus the broad range of anti-atherogenic, antioxidant and anti-apoptotic protection afforded by garlic may be extended to its neuroprotective action, helping to reduce the risk of dementia, including vascular dementia and AD. Key words: garlic, anti-atherogenic, anti-oxidant, anti-apoptotic, neuroprotective |
| Databáze: | OpenAIRE |
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