An Institutional experience with primary hyperparathyroidism in the elderly over two decades
| Autor: | Tracy S. Wang, Sophie Dream, Tina W.F. Yen, Douglas B. Evans, Kayla O’Sullivan, Ioanna G. Mazotas, Kara Doffek |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Parathyroidectomy Pediatrics medicine.medical_specialty Time Factors medicine.medical_treatment Disease Severity of Illness Index 03 medical and health sciences Postoperative Complications 0302 clinical medicine Disease severity Age groups Patient age medicine Humans Vitamin D Aged Retrospective Studies Retrospective review business.industry Age Factors General Medicine Hyperparathyroidism Primary medicine.disease Treatment Outcome Parathyroid Hormone Curative treatment 030220 oncology & carcinogenesis Preoperative Period Recurrent Laryngeal Nerve Injuries Calcium Female 030211 gastroenterology & hepatology Surgery business Hospitals High-Volume Primary hyperparathyroidism |
| Zdroj: | The American Journal of Surgery. 222:549-553 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2021.01.027 |
| Popis: | Parathyroidectomy is the only curative treatment for primary hyperparathyroidism (pHPT) and is associated with low morbidity. This study examined the severity of disease and outcomes of parathyroidectomy based on patient age at a high-volume institution.This is a retrospective review of sporadic pHPT patients who underwent initial parathyroidectomy. To study disease severity over time, patients were divided into timeframes: 1999-2007, 2007-2012, and 2013-2018. Elderly was defined as age ≥75 years.Over time, the elderly had progressively lower preoperative calcium (11.0, 10.7, 10.7; p = 0.05) and PTH (150.4, 111.9, 107.9; p 0.001) levels. By age, there was no difference in preoperative calcium (10.8, 10.9; p = 0.91) or in rates of recurrent laryngeal nerve injury, hypoparathyroidism, or persistent/recurrent pHPT.Over the 3 time periods of the study, elderly patients had progressively lower calcium and PTH levels. There was no difference in endocrine-specific complications between the age groups, suggesting that parathyroidectomy in the elderly is safe and therefore, age-associated morbidity should not preclude parathyroidectomy. |
| Databáze: | OpenAIRE |
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