High plasma soluble levels of the immune checkpoint HLA-G molecule among bodybuilders

Autor: Celso T. Mendes-Junior, Talita Morais Fernandes, Eduardo Antônio Donadi, Ana Paula Morais Fernandes, Milena Cristina de Paula, Paulin Sonon, Enrico Fuini Puggina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Muscle Physiology
Physiology
Adipose tissue
Biochemistry
Fats
0302 clinical medicine
Immune Physiology
HLA-G
Medicine and Health Sciences
Public and Occupational Health
Young adult
Immune Response
Innate Immune System
Multidisciplinary
Muscle Biochemistry
Lipids
Sports Science
LEVANTAMENTO DE PESO
Adipose Tissue
Connective Tissue
Cytokines
Medicine
Female
Anatomy
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Weight Lifting
Science
Immunology
030209 endocrinology & metabolism
Inflammation
Human leukocyte antigen
Young Adult
03 medical and health sciences
Signs and Symptoms
Immune system
Internal medicine
medicine
Humans
Sports and Exercise Medicine
Exercise
HLA-G Antigens
business.industry
Case-control study
Biology and Life Sciences
Physical Activity
Molecular Development
Immune checkpoint
Biological Tissue
030104 developmental biology
Endocrinology
Physical Fitness
Immune System
Case-Control Studies
Clinical Medicine
business
Biomarkers
Developmental Biology
Zdroj: PLoS ONE, Vol 15, Iss 9, p e0238044 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
ISSN: 1932-6203
Popis: IntroductionStudies report that intense physical activity influences the down-regulation of immune function in athletes as well as the interaction between adipose tissue and the immune system.AimThis study aimed to compare the plasma soluble levels of the immune checkpoint HLA-G (sHLA-G) molecule with the fat mass and muscle mass index among 77 bodybuilders and 64 controls.ResultsThe comparisons of the percentage of body fat (%BF) revealed that the groups of male and female bodybuilders showed a statistically significant reduction in the percentage of body fat when compared to their control group, (P ConclusionOur results showed that in bodybuilders with less body fat, the systemic levels of soluble HLA-G, an immunological molecule with recognized immunosuppressive function, are significantly higher and suggest that this immune mechanism may corroborate the immunosuppressive state in athletes undergoing intense and prolonged physical training.
Databáze: OpenAIRE
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