Assessment methods for aspirin-mediated platelet antiaggregation in type 2 diabetic patients: degree of correlation between 2 point-of-care methods
| Autor: | Jose Maria Cubero Gomez, Luis Pastor Torres, Pastor L. Pérez Santigosa, Francisco Javier Molano Casimiro, Maria Asunción Navarro Puerto, Juan Acosta Martínez, Francisco Sánchez Burguillos, Maria Isabel De Mier Barragan |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Platelet Function Tests Concordance medicine.medical_treatment Point-of-Care Systems Gastroenterology Statistics Nonparametric Percutaneous Coronary Intervention Internal medicine Diabetes mellitus medicine Humans Platelet Prospective Studies Prospective cohort study Pharmacology Aspirin business.industry Percutaneous coronary intervention Drug-Eluting Stents medicine.disease Diabetes Mellitus Type 2 Conventional PCI Female Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 64(1) |
| ISSN: | 1533-4023 |
| Popis: | AIMS Impaired response to antiplatelet therapy in diabetic patients results in a higher incidence of drug-eluting stent thrombosis. This study determined the prevalence of high on-aspirin (AS) platelet reactivity in type 2 diabetic patients treated with percutaneous coronary intervention (PCI) using the VerifyNow Aspirin Assay (VN) and platelet function analyzer PFA-100 (PFA-100) and analyzed the correlation between both methods. METHODS Type 2 diabetic patients (100) with non-ST-elevation acute coronary syndrome who underwent PCI and Xience V drug-eluting stent implantation were included in this study. After PCI, platelet antiaggregation mediated by acetylsalicylic acid was assessed by VN and PFA-100. The degree of correlation and concordance was then determined. RESULTS When assayed with VN, 7% of the patients were nonresponders to aspirin (aspirin reaction units >550), and when assayed with PFA-10, 41% were nonresponders (closure time |
| Databáze: | OpenAIRE |
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