The metabolism of arachidonic acid in the isolated tracheal and lung strip preparations of guinea-pigs
| Autor: | H. W. Mitchell, M. A. Denborough |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Contraction (grammar) Guinea Pigs Arachidonic Acids In Vitro Techniques chemistry.chemical_compound Internal medicine medicine Animals Prostaglandin E2 Lung Contractile response Metabolism respiratory system Trachea Thromboxane B2 Endocrinology medicine.anatomical_structure chemistry Arachidonic acid medicine.symptom Muscle Contraction Muscle contraction medicine.drug |
| Zdroj: | Lung. 158:121-129 |
| ISSN: | 1432-1750 0341-2040 |
| DOI: | 10.1007/bf02713714 |
| Popis: | The effect of arachidonic acid (AA) on tension in guinea-pig isolated lung strips and tracheas was investigated. AA (10−5 M) caused relaxation in the trachea and contraction in the lung strip. In lung strips the AA-induced contractions were inhibited by indomethacin (10−5 M), 5, 8, 11, 14-eicosatetraynoic acid (5 × 10−5 M) and L 8027 (5 × 10−7 M) but not by imidazole (up to 2 × 10−3 M). Material which co-chromatographed with thromboxane B2 (TXB2) was shown to be released from lung strips challengend with14CAA. L 8027 abolished TXB2 production whereas imidazole did not. These results indicate that AA is metabolised differently in central and peripheral airways. In the trachea prostaglandin E2 may mediate relaxation, whereas in lung strips material which co-chromatographs with TXB2 is associated with a contractile response to AA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink