Chlortetracycline in swine-bioavailability and pharmacokinetics in fasted and fed pigs
| Autor: | R.F. Bevill, W. F. Hall, C. R. Kilroy, Gary D. Koritz, D. P. Bane |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Chlortetracycline medicine.medical_specialty Time Factors Metabolic Clearance Rate Swine Chlortetracycline Hydrochloride Administration Oral Biological Availability Oxytetracycline Animal science Pharmacokinetics Internal medicine medicine Animals Pharmacology Volume of distribution General Veterinary Plasma samples Chemistry Total body Fasting Bioavailability Endocrinology Injections Intra-Arterial Female medicine.drug |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 13:49-58 |
| ISSN: | 0140-7783 |
| Popis: | Chlortetracycline hydrochloride was administered intra-arterially (11 mg/kg) and as an oral drench (33 mg/kg) to ten 21.0-31.5-kg pigs. Five of the pigs were fasted 18 h prior to dosing and five of the pigs were fed ad libitum prior to dosing. The mean volume of distribution determined by area-under-the-curve calculations for the fasted pigs (0.967 +/- 0.210 l/kg) was significantly less (P less than 0.05) than the mean volume of distribution for the fed pigs (1.39 +/- 0.31 l/kg). Mean total body clearance of the drug was also significantly less (P less than 0.05) in the fasted pigs (0.165 +/- 0.055 l/kg/h) as compared to the fed pigs (0.307 +/- 0.053 l/kg/h). The elimination constants (beta) were not found to be statistically different (P less than 0.05): 0.1811 +/- 0.0057 for the fasted pigs; 0.2260 +/- 0.0461 for the fed pigs. The bioavailability for both groups was similar; 19.12 +/- 8.3% for the fasted pigs and 17.88 +/- 5.3% for the fed pigs. In a second experiment three groups of six pigs which weighed 34.5-44.1 kg were fed a corn-soy diet ad libitum. The rations were fortified with chlortetracycline at 100, 400 or 1000 mg chlortetracycline hydrochloride/kg feed. Chlortetracycline concentrations were determined in plasma samples collected over a 6-day period. Plasma chlortetracycline concentrations reach a plateau within 24 h after initial access to the trial diets and were highly correlated with the dose of the drug consumed (r2 = 0.97). |
| Databáze: | OpenAIRE |
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